Skincare Panel Report Description



The most comprehensive genetic report on Skincare available on the market today for your raw DNA data.

NutraHacker reports mutations (single nucleotide polymorphisms) in the uploaded genome. Genes not reported in this report are either normal, not actionable, or not currently detected by NutraHacker. Mutations whose RSID has an asterisk (*) have been imputed. The expected allele is the one seen in a normally functioning gene. The high-risk alleles reported are the ones measured from the uploaded genome. NutraHacker reports the effects of these mutations as discovered by published empirical data and suggests nutritional supplements that can mitigate potential issues caused by these mutations.

Importantly, the Skincare Panel goes beyond just SNP-level reporting—it also calculates overall gene functionality based on cumulative genetic variation. This provides a more complete picture of how key skincare-related genes are working (or not working) in your body, even when no single SNP tells the full story.

This report is meant to serve as a guide for nutritional supplementation for the owner of the genome and is not applicable to any other individual. Supplement quantities and dosages are not included as they are indicated on the purchased product. Multiple recommendations for the same supplement does not mean that the dosage should be multiplied. In the case of a conflict (such as a particular vitamin being both encouraged and discouraged), the owner of the genome should assess his/her own personal biology to decide whether to include or discard that particular supplement. Please see our FAQ for advice on conflicts.

Your skin’s health and appearance are deeply influenced by genetics, affecting everything from collagen strength and hydration to inflammation, elasticity, and pigmentation. The NutraHacker Skincare Panel analyzes 117 key SNPs across 60 genes tied to skin vitality and aging, offering a comprehensive look at how your body maintains, repairs, and protects your skin. This goes beyond surface-level traits, mapping gene functionality in areas such as detoxification, UV protection, barrier integrity, and antioxidant capacity.

Imagine understanding your skin on a molecular level, and having a personalized roadmap to optimize it. Our advanced genetic panel decodes how your DNA influences traits like wrinkles, acne, texture, and sun sensitivity, while providing actionable, science-backed insights to support healthier, more resilient skin. As new research emerges, NutraHacker’s continuously updated platform ensures your recommendations evolve, empowering you to unlock your skin’s full genetic potential.

The genes analyzed in the Skincare Panel include:

  1. ABCA1 - Involved in lipid transport and cholesterol efflux, supporting the skin's barrier function and preventing dryness or irritation.
  2. ABCC11 - Determines earwax type and apocrine sweat gland secretion, influencing body odor and the effectiveness of deodorants in skincare.
  3. APEX1 - Plays a role in DNA base excision repair, protecting skin cells from oxidative damage and aging caused by environmental stressors.
  4. AQP3 - Encodes a water channel protein essential for skin hydration and maintaining moisture balance in the epidermis.
  5. AR - Androgen receptor gene, linked to conditions like acne, oily skin, and hair loss due to hormone sensitivity in skin cells.
  6. CAT - Catalase enzyme gene, acts as an antioxidant to neutralize hydrogen peroxide, reducing oxidative stress and skin aging.
  7. CDSN - Corneodesmosin, crucial for cell adhesion in the stratum corneum, maintaining skin barrier integrity and preventing moisture loss.
  8. CLDN1 - Claudin-1, a tight junction protein that strengthens the skin barrier, reducing permeability and protecting against irritants.
  9. COL1A1 - Type I collagen alpha-1 chain, key for skin structure and elasticity, mutations can lead to wrinkles and reduced firmness.
  10. COL1A2 - Type I collagen alpha-2 chain, works with COL1A1 to form collagen fibers, essential for skin strength and anti-aging.
  11. COL5A1 - Type V collagen alpha-1 chain, involved in fibril assembly, contributing to skin's tensile strength and wound healing.
  12. COMT - Catechol-O-methyltransferase, metabolizes catecholamines and estrogens, influencing skin pigmentation and hormone-related conditions.
  13. CYP17A1 - Involved in steroid hormone synthesis, affecting androgen levels that can contribute to acne and seborrhea.
  14. CYP1A1 - Cytochrome P450 enzyme, detoxifies environmental pollutants, protecting skin from damage caused by toxins and UV exposure.
  15. ELN - Elastin, provides skin elasticity and resilience, degradation leads to sagging and wrinkles in aging skin.
  16. EPHX1 - Epoxide hydrolase 1, detoxifies reactive epoxides from pollutants, reducing skin inflammation and cancer risk.
  17. ERCC1 - Part of nucleotide excision repair, fixes UV-induced DNA damage, preventing photoaging and skin cancer.
  18. ERCC2 - Involved in DNA repair, protects against UV damage, maintaining skin health and reducing mutation risks.
  19. FADS1 - Fatty acid desaturase 1, involved in polyunsaturated fatty acid metabolism, supporting skin barrier lipids and reducing dryness.
  20. FBLN5 - Fibulin-5, essential for elastic fiber assembly, contributing to skin's elasticity and preventing premature aging.
  21. FBN1 - Fibrillin-1, forms microfibrils in extracellular matrix, crucial for skin elasticity and connective tissue disorders like Marfan syndrome affecting skin.
  22. FCGR2A - Fc gamma receptor IIA, involved in immune responses, influencing skin inflammation and allergic reactions.
  23. FLG - Filaggrin, vital for skin barrier formation, mutations linked to atopic dermatitis, ichthyosis, and dry skin.
  24. GBA - Glucosylceramidase, processes skin lipids, deficiencies cause Gaucher disease with skin manifestations like dryness and scaling.
  25. GPX1 - Glutathione peroxidase 1, antioxidant enzyme that protects skin cells from peroxide damage and oxidative stress.
  26. HERC2 - Regulates OCA2 expression, influencing eye and skin pigmentation, affecting melanin levels and UV protection.
  27. HLA-C - Human leukocyte antigen C, involved in immune response, associated with psoriasis and other inflammatory skin conditions.
  28. IGF1 - Insulin-like growth factor 1, promotes cell growth and collagen production, influencing skin aging and wound healing.
  29. IL10 - Interleukin-10, anti-inflammatory cytokine, modulates immune responses to reduce skin inflammation in conditions like eczema.
  30. IL12B - Interleukin-12 beta, pro-inflammatory, involved in psoriasis and other autoimmune skin diseases.
  31. IL13 - Interleukin-13, promotes allergic inflammation, linked to atopic dermatitis and skin barrier dysfunction.
  32. IL1A - Interleukin-1 alpha, pro-inflammatory, involved in skin irritation, acne, and wound healing processes.
  33. IL1B - Interleukin-1 beta, key in inflammation, contributes to acne, psoriasis, and UV-induced skin damage.
  34. IL6 - Interleukin-6, involved in inflammation and wound healing, elevated in aging skin and inflammatory disorders.
  35. IRF4 - Interferon regulatory factor 4, influences hair color and skin pigmentation, affecting tanning response.
  36. KITLG - KIT ligand, involved in melanocyte development, affecting skin pigmentation and vitiligo susceptibility.
  37. LOX - Lysyl oxidase, cross-links collagen and elastin, essential for skin firmness and elasticity.
  38. LOXL1 - Lysyl oxidase-like 1, similar to LOX, supports extracellular matrix stability, linked to skin laxity.
  39. MC1R - Melanocortin 1 receptor, regulates melanin production, variants cause fair skin, red hair, and increased UV sensitivity.
  40. MMP9 - Matrix metalloproteinase 9, breaks down extracellular matrix, involved in skin aging, wrinkles, and wound remodeling.
  41. NQO1 - NAD(P)H quinone dehydrogenase 1, detoxifies quinones, protecting skin from oxidative damage and pollution.
  42. OCA2 - Oculocutaneous albinism II, regulates melanin synthesis, affecting skin and hair color and UV protection.
  43. P4HA1 - Prolyl 4-hydroxylase alpha-1, essential for collagen stability, supporting skin structure and anti-aging.
  44. PON1 - Paraoxonase 1, antioxidant enzyme, protects against lipid peroxidation in skin, reducing aging effects.
  45. PPARG - Peroxisome proliferator-activated receptor gamma, regulates sebum production and adipogenesis, influencing acne and skin hydration.
  46. SLC24A4 - Solute carrier family 24 member 4, involved in ion transport for melanogenesis, affecting skin pigmentation.
  47. SLC24A5 - Solute carrier family 24 member 5, key in melanin production, variants determine lighter or darker skin tones.
  48. SLC45A2 - Solute carrier family 45 member 2, involved in melanosome pH regulation, influencing pigmentation and albinism.
  49. SOD2 - Superoxide dismutase 2, mitochondrial antioxidant, protects against oxidative stress in skin aging and UV damage.
  50. SPINK5 - Serine protease inhibitor Kazal-type 5, regulates skin desquamation, mutations cause Netherton syndrome with barrier defects.
  51. TGFB1 - Transforming growth factor beta 1, regulates cell growth and fibrosis, key in wound healing and scar formation.
  52. TIMP1 - Tissue inhibitor of metalloproteinases 1, inhibits MMPs, balancing matrix remodeling to prevent excessive skin aging.
  53. TNF - Tumor necrosis factor, pro-inflammatory cytokine, involved in psoriasis, acne, and UV-induced inflammation.
  54. TYR - Tyrosinase, catalyzes melanin synthesis, essential for pigmentation and protection against UV radiation.
  55. TYRP1 - Tyrosinase-related protein 1, stabilizes tyrosinase, involved in eumelanin production for skin color.
  56. VDR - Vitamin D receptor, mediates vitamin D effects on skin cell differentiation, proliferation, and psoriasis treatment.
  57. VEGFA - Vascular endothelial growth factor A, promotes angiogenesis, crucial for wound healing and skin repair.
  58. XPA - Xeroderma pigmentosum complementation group A, DNA repair protein, prevents UV-induced damage and skin cancer.
  59. XRCC1 - X-ray repair cross-complementing 1, involved in base excision repair, protecting skin from environmental mutagens.
  60. XRCC3 - X-ray repair cross-complementing 3, part of homologous recombination repair, maintaining genomic stability in skin cells.
The NutraHacker Skincare Panel is accessible exclusively via the NutraHacker App. Upload raw DNA data to get your very own personalized Skincare Panel at the NutraHacker Store.