Gene IL1B
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Also known as
interleukin 1 beta, IL-1β, catabolinOverview
IL1B (Interleukin 1 Beta) encodes a major proinflammatory cytokine produced primarily by activated macrophages. IL-1β is synthesized as an inactive precursor and requires cleavage by caspase-1 for activation and secretion. It plays central roles in inflammation, fever response, and immune cell activation, and is a key mediator of acute and chronic inflammatory diseases.Variants in IL1B, particularly the -511C/T polymorphism, influence IL-1β production levels and have been associated with susceptibility to various inflammatory conditions including periodontal disease, gastric cancer, and inflammatory bowel disease. Higher IL-1β producers may mount stronger inflammatory responses but also face greater risk of chronic inflammatory damage.
Understanding your IL1B genetic status provides insights into inflammatory capacity and disease susceptibility. This information is relevant for understanding periodontal disease risk, inflammatory responses to infection, and potentially guiding anti-inflammatory interventions.