Gene FLG

Also known as

filaggrin, ATOD2, FLG-2

Overview

FLG (Filaggrin) encodes a key structural protein essential for maintaining the skin barrier. Filaggrin is expressed in the outermost layer of the epidermis where it aggregates keratin filaments and contributes to the formation of natural moisturizing factors (NMF) that keep skin hydrated and protected.

Loss-of-function mutations in FLG are the strongest known genetic risk factors for atopic dermatitis (eczema) and are also associated with increased risk of asthma, allergic rhinitis, and food allergies. Approximately 10% of Europeans carry at least one FLG null mutation. These mutations lead to impaired skin barrier function, increased transepidermal water loss, and enhanced allergen penetration.

Understanding your FLG genetic status is valuable for skin health management. Individuals with FLG variants benefit from aggressive moisturization, barrier repair skincare products, and strategies to minimize skin irritants. This genetic information can guide personalized skincare routines and help prevent the atopic march.

NutraHacker Raw DNA Analysis Products that include this gene

• Skincare Panel
• Histamine/Allergy Panel

Upload raw DNA data to get your very own analysis of gene FLG through your personalized DNA reports.