Gene VEGFA
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Also known as
Vascular endothelial growth factor A, VEGF, VPF, MGC70609Overview
VEGFA (Vascular Endothelial Growth Factor A) is the most abundant and well-characterized member of the VEGF family of angiogenic growth factors. This gene encodes a glycoprotein that binds to VEGF receptors (primarily VEGFR1 and VEGFR2) on endothelial cells, triggering signaling cascades that promote blood vessel formation, endothelial cell survival, and vascular permeability. Multiple isoforms of VEGFA exist due to alternative splicing, each with distinct biological properties.Genetic polymorphisms in VEGFA influence circulating VEGF levels and tissue-specific expression patterns. These variants have been associated with differences in exercise-induced angiogenesis, altitude adaptation, cardiovascular disease risk, and cancer susceptibility. In athletic populations, certain VEGFA genotypes correlate with enhanced capillary density in skeletal muscle, improved oxygen delivery, and better endurance performance. The VEGFA response to exercise training shows significant inter-individual variability based on genetic background.
Beyond athletic performance, VEGFA plays critical roles in wound healing, skin health, and aging. It promotes collagen synthesis and tissue remodeling but can also contribute to skin fragility and visible blood vessels when dysregulated. Understanding VEGFA genetics enables personalized recommendations for training optimization, recovery strategies, skincare interventions, and assessment of cardiovascular and cancer risk.