Gene AQP3
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Also known as
GIL, AQP-3Overview
AQP3 (Aquaporin 3) encodes aquaglyceroporin-3, a membrane channel protein that facilitates the transport of water and small solutes such as glycerol and urea across cell membranes. AQP3 is highly expressed in the epidermis, where it plays a crucial role in maintaining skin hydration and barrier function.In the skin, AQP3 is localized in the plasma membrane of keratinocytes and facilitates glycerol transport, which is essential for stratum corneum hydration, skin elasticity, and wound healing. Reduced AQP3 expression or function has been associated with dry skin, impaired wound healing, and accelerated skin aging. The gene is also expressed in the kidney and other tissues where it contributes to fluid balance.
Understanding your AQP3 genetic status is particularly relevant for skincare and dermatological health. Individuals with certain AQP3 variants may benefit from glycerol-containing moisturizers and enhanced hydration strategies to support optimal skin function.