Gene CDSN
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Also known as
S, HTSS, corneodesmosinOverview
CDSN (Corneodesmosin) encodes a protein essential for skin barrier integrity and the controlled desquamation (shedding) of the outermost skin cells. Corneodesmosin is a component of corneodesmosomes, the specialized junctions that hold together cells in the stratum corneum, and its regulated degradation is necessary for normal skin renewal.Variants in CDSN have been associated with psoriasis susceptibility, as the gene lies within the PSORS1 psoriasis susceptibility locus on chromosome 6p21. Loss-of-function mutations cause peeling skin syndrome type 1 (generalized type), characterized by lifelong superficial skin peeling, erythema, and sometimes hair abnormalities. The gene's location in the MHC region also links it to various immune-mediated conditions.
Understanding your CDSN genetic status provides insights into skin barrier function and inflammatory skin disease susceptibility. This information is relevant for understanding psoriasis risk and for evaluating patients with unexplained skin peeling or barrier dysfunction syndromes.