Gene IRF4
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Also known as
interferon regulatory factor 4, MUM1, LSIRF, NF-EM5Overview
IRF4 (Interferon Regulatory Factor 4) encodes a transcription factor that regulates gene expression in immune cells and melanocytes. In the immune system, IRF4 is essential for the development and function of T and B lymphocytes. In melanocytes, it regulates pigmentation genes and plays a key role in determining skin, hair, and eye color.Variants in IRF4 are strongly associated with pigmentation traits, sun sensitivity, freckling, and melanoma risk. The rs12203592 polymorphism is one of the most significant genetic predictors of sensitivity to sunlight and skin cancer susceptibility. People with risk variants typically have lighter skin, blonde hair, and increased sun sensitivity.
Understanding your IRF4 genetic status provides insights into pigmentation, sun sensitivity, and melanoma risk. This information is valuable for guiding sun protection strategies and understanding individual responses to UV radiation.