Gene FCGR2A
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Also known as
CD32, CD32A, FcgammaRIIa, Fc gamma receptor IIaOverview
FCGR2A (Fc Gamma Receptor IIa) encodes a low-affinity receptor for the Fc portion of IgG antibodies, expressed on phagocytic cells including macrophages, neutrophils, and dendritic cells. This receptor mediates phagocytosis of antibody-coated pathogens and immune complexes, playing a central role in antibody-dependent cellular immune responses.A common polymorphism (H131R) in FCGR2A affects receptor function, with the R131 variant having lower affinity for IgG2 antibodies. This variant has been associated with susceptibility to infections by encapsulated bacteria, autoimmune diseases including systemic lupus erythematosus, and response to therapeutic monoclonal antibodies in cancer treatment.
Understanding your FCGR2A genetic status provides insights into immune function and may be relevant for understanding susceptibility to certain infections and autoimmune conditions. This information is also important for predicting response to antibody-based cancer therapies.