Gene IL12B
Back to Curriculum
Also known as
interleukin 12B, IL-12B, p40, CLMF2, natural killer cell stimulatory factor 2Overview
IL12B (Interleukin 12B) encodes the p40 subunit of interleukin-12 (IL-12) and interleukin-23 (IL-23), two important cytokines in immune regulation. IL-12 promotes Th1 immune responses and interferon-gamma production, crucial for defense against intracellular pathogens. IL-23 supports Th17 responses involved in mucosal immunity and autoimmunity. IL12B is produced by dendritic cells and macrophages upon pathogen recognition.Variants in IL12B have been associated with susceptibility to psoriasis, inflammatory bowel disease, and other autoimmune conditions. The gene is a target for biologic therapies like ustekinumab, which blocks both IL-12 and IL-23 signaling. Genetic variation in IL12B can affect cytokine production and immune response intensity.
Understanding your IL12B genetic status provides insights into immune regulation and inflammatory response patterns. This information is relevant for understanding autoimmune disease susceptibility and potentially guiding anti-inflammatory or immunomodulatory approaches.