Also known as
GPX1 is a gene that encodes a protein called glutathione peroxidase 1. This protein is an antioxidant enzyme that plays a role in the body's defense against oxidative stress. It helps to protect cells and tissues from damage caused by free radicals, which are highly reactive molecules that can be harmful to cells if their levels become too high. Glutathione peroxidase 1 works by catalyzing the reduction of hydroperoxides (compounds that contain hydrogen and oxygen atoms) to their corresponding alcohols using reduced glutathione (GSH) as a cofactor. This reaction helps to neutralize the harmful effects of free radicals and other reactive oxygen species.
Glutathione peroxidase 1 is found in many tissues throughout the body, including the liver, kidney, spleen, and pancreas. It is involved in a number of important physiological processes, including the detoxification of xenobiotics (foreign chemicals that enter the body), the regulation of immune function, and the maintenance of structural integrity of cell membranes. Deficiencies in GPX1 activity have been linked to a number of health conditions, including cardiovascular disease, cancer, and neurological disorders.
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