Gene HLA-C

Also known as

major histocompatibility complex class I C, HLAC, MHC class I antigen C

Overview

HLA-C (Human Leukocyte Antigen C) encodes an MHC class I molecule that presents peptide antigens to cytotoxic T lymphocytes. Unlike HLA-A and HLA-B, HLA-C is also a major ligand for killer immunoglobulin-like receptors (KIRs) on natural killer cells, making it important for both adaptive and innate immunity. HLA-C expression levels vary between alleles and influence immune responses.

HLA-C alleles are strongly associated with psoriasis susceptibility. HLA-C*06:02 is the primary genetic risk factor for psoriasis, found in approximately 60% of patients with early-onset disease. HLA-C variants also influence HIV disease progression, with certain alleles associated with better viral control. Additionally, HLA-C plays a role in pregnancy, affecting placental development through interaction with maternal NK cells.

Understanding your HLA-C genetic status provides insights into autoimmune disease risk, infection outcomes, and immune regulation. This information is particularly relevant for understanding psoriasis susceptibility and may inform treatment approaches for inflammatory skin conditions.

NutraHacker Raw DNA Analysis Products that include this gene

• Skincare Panel
• WGS Pharmacogenetics Panel

Upload raw DNA data to get your very own analysis of gene HLA-C through your personalized DNA reports.