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COMT (Catechol-O-Methyltransferase) is a gene that codes for an enzyme called catechol-O-methyltransferase. This enzyme is involved in the breakdown of the neurotransmitters dopamine, epinephrine, and norepinephrine. Specifically, COMT catalyzes the transfer of a methyl group from S-adenosylmethionine to the catecholamines, resulting in their inactivation. COMT is important for the regulation of neurotransmitter levels in the brain and has been implicated in a number of neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and attention deficit hyperactivity disorder (ADHD). There are several variants of the COMT gene, and variations in this gene have been associated with differences in COMT enzyme activity and risk for certain disorders.

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