Gene CLDN1
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Also known as
CLD1, SEMP1, ILVASC, claudin 1Overview
CLDN1 (Claudin 1) encodes a major component of tight junctions, the specialized cell-cell adhesion structures that create barriers between cells in epithelial and endothelial tissues. Claudin-1 is essential for skin barrier function, preventing water loss and blocking entry of pathogens and allergens.Mutations in CLDN1 cause neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome, a rare disorder characterized by ichthyosis (scaly skin), scarring cholangitis (liver disease), and alopecia. Variants in CLDN1 have also been associated with atopic dermatitis susceptibility, reflecting its critical role in skin barrier integrity. The gene is also a receptor for hepatitis C virus entry into liver cells.
Understanding your CLDN1 genetic status provides insights into skin barrier function and susceptibility to conditions like eczema. This information is relevant for personalized skincare approaches and understanding risk for barrier-related skin conditions.