Gene NQO1

Also known as

NAD(P)H quinone dehydrogenase 1, NAD(P)H:quinone oxidoreductase, DT-diaphorase, QR1

Overview

NQO1 (NAD(P)H Quinone Dehydrogenase 1) encodes an enzyme that detoxifies quinones through two-electron reduction, preventing generation of reactive oxygen species. NQO1 is part of the cellular antioxidant defense system and is induced by oxidative stress through the Nrf2 pathway. The enzyme also stabilizes the tumor suppressor p53 and is important for vitamin K metabolism.

The Pro187Ser (C609T, rs1800566) polymorphism results in a virtually non-functional enzyme when homozygous. The NQO1*2 allele is associated with reduced protection against oxidative stress, increased susceptibility to certain cancers, and altered response to chemotherapeutic agents that require NQO1 activation. The variant also affects coenzyme Q10 and vitamin K metabolism.

Understanding your NQO1 genetic status provides insights into antioxidant capacity and quinone metabolism. This information is relevant for understanding oxidative stress protection, cancer susceptibility, and potentially vitamin K-dependent clotting factor activity.

NutraHacker Raw DNA Analysis Products that include this gene

• Complete Mutation Nutrition Report
• Skincare Panel

Upload raw DNA data to get your very own analysis of gene NQO1 through your personalized DNA reports.