Gene EPHX1
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Also known as
EPHX, MEH, HYL1, epoxide hydrolase 1Overview
EPHX1 (Epoxide Hydrolase 1) encodes a microsomal enzyme that detoxifies reactive epoxide intermediates formed during phase I metabolism of drugs and environmental chemicals. This enzyme converts potentially genotoxic epoxides to less harmful dihydrodiols, playing a critical role in the body's defense against carcinogens and oxidative stress.Two common polymorphisms in EPHX1 (Y113H and H139R) affect enzyme activity and have been studied for associations with cancer risk, particularly lung cancer in smokers. The enzyme also metabolizes epoxides derived from polyunsaturated fatty acids, which are important signaling molecules affecting blood pressure, inflammation, and pain. EPHX1 activity can vary over 50-fold between individuals.
Understanding your EPHX1 genetic status provides insights into detoxification capacity and potentially cancer susceptibility. Individuals with reduced EPHX1 activity may be more susceptible to environmental carcinogens and may benefit from enhanced antioxidant support and reduced exposure to known environmental toxins.