Hey there nutrahacker,

Happy Independence Day from all of us at NutraHacker!

We are thrilled to share some of our latest advancements with you. We’ve recently launched NutraPedia, our comprehensive resource for all things health and wellness. Additionally, we're excited to announce our upcoming Hormone Panel, designed to provide deeper insights into your hormonal health.

To celebrate this special occasion, we are offering a 30% discount on all standard reports from July 4th to July 6th. Use the coupon code 'NUTRAJULY4' at checkout to take advantage of this limited-time offer.

Thank you for being a part of our journey. Here's to your health and wellness!

Access the NutraHacker 4th of July Sale!

Best regards,

Dr. Jon Vinea and Mark Austin Wagoner

Co-founders, NutraHacker, LLC

Dear NutraHacker Community,

We are thrilled to announce a significant update to NutraPedia that will enhance your experience and help you achieve your health goals more efficiently. NutraPedia now includes the ability to search by goals and results!

What's New?

• Search by Goals: Whether you aim to improve your energy levels, enhance cognitive function, support heart health, or achieve any other wellness goal, you can easily find the supplements that align with your objectives.
• Search by Results: Discover which supplements are known to produce specific results based on scientific research and user experiences.

Why This Matters

We understand that navigating the world of supplements can be overwhelming. By allowing you to search by goals and results, we aim to provide a more personalized and efficient way for you to find the most relevant supplements for your unique needs.

How to Use the New Features

1. Visit NutraPedia.
2. Enter your desired goal or result in the search box.
3. Explore the curated list of supplements tailored to your search.

We hope these new features will make your journey to optimal health even more straightforward and effective. Your feedback is invaluable to us, so please let us know how these updates are working for you.

If you have used NutraPedia before, be sure to clear your browser's cache to use the latest version.

Thank you for being a part of the NutraHacker community. Here's to your health and wellness!

Best regards,

The NutraHacker Team

Dear nutrahacker,

We are excited to announce an update to our WGS HLA analysis.

HLA is one important way that our bodies recognize self versus non-self and set our immune system to attack foreign material in our bodies. It is how we can recognize a virus-infected cell, bacteria, or a transplanted organ. HLA also unfortunately is intimately involved with allergies.

Our PharmaShield already shows if a person is at higher risk of allergy to specific medications, and now it is updated to include risk of allergies to things like bee stings, pollen, mold, shrimp, and gluten. Gluten allergy is also known as Celiac disease. Our previous Celiac report is based on HLA predictions from microarray data, and our results with our own microarray and WGS data shows that these results are consistent and in agreement.

What is the HLA Gene Analysis?

Our HLA gene analysis involves examining your DNA to identify HLA genotypes which then are translated (pun intended) to serotypes that are linked to various allergies. By understanding your HLA serotypes, we can note your susceptibility to certain allergies much like the more rudimentary Celiac report.

Benefits of the HLA Gene Analysis:

• Personalized Allergy Management: Gain insights into which allergies you are more likely to be susceptible to, allowing for better prevention and management strategies.
• Improved Health Outcomes: Understanding your genetic predisposition to allergies can lead to more targeted treatments and dietary recommendations, improving your overall health.
• Family Planning: Knowledge of your HLA serotypes can also be beneficial for family planning, giving potential parents insights into allergy risks for their children.

How Can You Use This Information?

1. Dietary Adjustments: Customize your diet based on potential food allergies.
2. Environmental Modifications: Make changes in your home or work environment to avoid allergens you are susceptible to.
3. Healthcare Consultations: Share your results with healthcare providers to develop personalized treatment plans.

To learn more about this analysis and how it can benefit you, please see the WGS True Detox and PharmaShield (PGx) Panel demonstration or shoot us an email. We love communicating and sharing ideas.

Warm regards,

Dr Jonathan Vinea and Mark Austin Wagoner

Co-founders, NutraHacker, LLC

Dear nutrahacker,

We are reaching out to share some exciting insights into our latest advancements in HLA typing and its significant implications for pharmacogenetics and allergy susceptibility. At NutraHacker, we are committed to leveraging cutting-edge genetic insights to enhance personal health and wellness, and understanding your HLA status is a key part of this journey.

HLA Typing Now Included in PharmaShield Panel

We understand the importance of personalized healthcare. That's why we've expanded our pharmacogenetics panel to include Human Leukocyte Antigen (HLA) typing. The HLA system is a group of genes on chromosome 6 that code for proteins present on the surfaces of cells that are crucial for the immune system's recognition of foreign substances.

This addition comes at no extra charge and offers a deeper dive into how your genetic makeup can influence your body's response to medications. HLA typing is a powerful tool in pharmacogenomics, helping to identify potential drug sensitivities and guiding more personalized medication choices. This update aims to enhance medication safety and efficacy, tailored just for you.

Stevens-Johnson Syndrome (SJS) is a rare, serious disorder of the skin and mucous membranes (we strongly recommend you don't google images). It's usually a reaction to a medication or an infection. SJS is considered a medical emergency that requires hospitalization.

SJS is thought to be a type of hypersensitivity reaction, with genetics playing a role in the body's reaction to medication. Certain HLA types have been associated with an increased risk of developing SJS when exposed to specific medications.

For example, the HLA-B*1502 allele has been linked to a higher risk of SJS when individuals take certain anticonvulsant drugs. The reaction involves the activation of the body's immune system in a harmful way, leading to severe inflammation and cell death in the skin and mucous membranes.

Prevention involves avoiding the use of medications that have previously triggered SJS in the patient or avoiding drugs known to be high risk if the patient has a known genetic predisposition (e.g., carrying the HLA-B*1502 allele and avoiding certain anticonvulsants if of Asian descent). Because of the association between certain medications and SJS, genetic testing for specific HLA alleles before starting certain treatments can be an important preventive measure, reducing the risk of this severe reaction.

Upcoming: Mold and Food Allergies Insights

Our commitment to your health doesn't stop there. We're excited to announce that we will soon provide updates regarding mold and food allergies, directly linked to your HLA status. This forthcoming feature will offer valuable insights into potential allergy predispositions, enabling you to make informed decisions about your diet and environment. Stay tuned for this update, as we work diligently to bring you the latest in genetic health insights.

Last Chance: Take Advantage of Our Sale Before It Ends on February 29th!

As a reminder, our current sale is quickly coming to a close. If you've been considering deepening your understanding of your genetic profile or sharing the gift of health with others, now is the perfect opportunity. You can order without currently having your Whole Genome Sequencing (WGS) data ready, but you will eventually need your WGS data to access the PharmaShield and HLA panel. This sale ends on February 29th, so don't miss out on the chance to take advantage of our exclusive offers, available below:

Click here to Access the Initial Release Sale, Ending Soon

At NutraHacker, your health and satisfaction are our top priorities. We are here to support your journey towards optimal wellness with cutting-edge genetic insights. If you have any questions about your panel, our new features, or how to make the most of our current sale, please don't hesitate to reach out.

Thank you for choosing NutraHacker. We look forward to continuing to serve your health and wellness needs.

Warm regards,

Dr Jonathan Vinea and Mark Austin Wagoner
Co-founders, NutraHacker, LLC

P.S. On a different note, HLA typing opens up fascinating possibilities in the realm of genetic dating. The diversity of the HLA genes plays a role in natural attraction, with some studies suggesting that individuals may be subconsciously attracted to potential partners with dissimilar HLA types. This genetic diversity is believed to contribute to a healthier offspring immune system.

Dear NutraHackers,

The True Detox and PharmaShield PGx Panel has been updated to include CYP2D6 and other genes.

CYP2D6 is a major gene that metabolizes about 25% of prescription medications. Reacting poorly to a medication might be due to non-functional CYP2D6.

Besides breaking down drugs, liver enzymes sometimes activate them. Prodrugs are drugs that are inactive until our metabolism activates them. If we are lacking an enzyme that activates a prodrug, then the drug might be ineffective and/or have increased side effects.

CYP2D6 activates drugs like codeine (prodrug for morphine), dextromethorphan (DXM, ingredient in cough syrup), and ketamine (important for the studies using ketamine to treat depression). It also converts the SNRI depression medication venlafaxine (USA prescription rank 47th place) to its active form desvenlafaxine. If medications like codeine or DXM have made you feel terrible, CYP2D6 might be the reason why.

CYP2D6 also detoxifies multiple pesticides and fungicides, such as organophosphate, organochlorine, fipronil and carbendazim. Besides CYP2D6, the update also includes several new genes, bringing total coverage to the following list:

The True Detox and PharmaShield (PGx) Panel needs whole genome sequencing (WGS) raw data and will not work with 23andMe or Ancestry. It is worth it to get whole genome sequencing data if you do not currently have it. CYP2D6 is highly polymorphic and therefore needs WGS data to accurately assess what configuration each individual has.

To help you deepen your understanding of genes fundamental to detoxification and pharmacogenetics, we recently released our first book on Kindle, NutraHacker's Guide to Pharmacogenetics.

Our next projects will be to update the Journal Club with useful studies so that you can look up the useful research on just about every supplement (for free) and also completing an Human leukocyte antigen (HLA) panel. HLA has applications for knowing if there’s a risk for severe reactions to medications, organ donor matching, and even dating!

Sincerely,

Dr. Jon Vinea and Mark Austin Wagoner
Co-founders, NutraHacker, LLC

Hey there nutrahacker,

This December NutraHacker had its 10th birthday!

Since starting in 2013 we have grown in leaps and bounds, adding many more reports, expanding microarray data with imputation, processing whole genome sequencing raw data and recently launching our True Detox and PGx Panel. It has been quite the journey!

To commemorate turning 10, we will be offering a 50% off discount until Jan 1st, 2024. Use the coupon code 'NUTRA10Y' at checkout to take advantage.

To your health,

Dr. Jon Vinea and Mark Austin Wagoner
Co-founders, NutraHacker, LLC

Dear NutraHackers,

Did you know that the True Detox and PharmaShield (PGx) Panel is also a detoxification panel!? That's why we changed the name from Pharmacogenetics Panel. Looking at the diplotype summary table will help determine how these extremely important enzymes function overall.

Here are some natural and common toxins and the liver enzymes that detoxify them. If you have decreased function on any of these enzymes, you won’t detoxify them as well. Also, if you have increased enzyme function, you will detoxify them extra rapidly!

Updates to include natural compounds and toxins are on the way- much like our original free detoxification report but again in much more detail due to using WGS (Whole Genome Sequencing) data.

Our True Detox and PharmaShield (PGx) panel has been updated to add 1,028 new drugs to metabolic analysis! This includes significant additions such as Levothyroxine, Amlodipine, Losartan, Montelukast and Trazodone.

This panel can be a daunting tool to use, here are a couple tips to try out:

Select: under Gene Activity [non normal], and under Data Source [International and Dutch consortiums] and [FDA] groups to see published specific recommendations for your genetics. The links in the table go into much more depth, definitely check them out!

If a particular drug that you have taken in the past has made you feel terrible, try searching for the generic drug name and see if there is a genetic explanation in your liver enzymes (CYP2D6 is a big one and will be available soon).

Sincerely,

Dr. Jon Vinea and Mark Austin Wagoner
Co-founders, NutraHacker, LLC

Dear NutraHackers,

We're beyond excited to share a groundbreaking development in personalized healthcare – the launch of NutraHacker's True Pharmacogenetics (PGx) Panel for Whole Genome Sequencing (WGS)!

Why It's a Game-Changer:

For years, the dream of personalized genetics seemed just out of reach. Now, it's not just a dream – it's reality. Our True PGx Panel isn't just another product; it's a leap into the future of personalized health care.

What Makes Our PGx Panel Unique?

Continuous Evolution & Mobile-Friendly Access
We're committed to continuously enhancing the WGS PGx panel. Stay tuned for broader gene and Rx coverage. Plus, a mobile-friendly version is coming soon - perfect for on-the-go consultations!

Accessible Subscription Model
In our mission to make this revolutionary tool widely accessible, we're introducing an affordable subscription model, ensuring you always have the latest updates.

Special Preorder Offer!
Curious to learn more? Secure your preorder of the Whole Genome Sequencing (WGS) True Pharmacogenetics (PGx) Panel at an exclusive initial release price:

Click here to find out more about the initial release offer, with a free gift inside

Recommended WGS Services
If you're new to whole genome sequencing, here are some trusted services to get started:

• Nebula Genomics
• Sequencing.com
• Dante Labs
• WeGene

Don't miss this chance to embark on a journey of personalized healthcare like never before!

Sincerely,

Dr. Jon Vinea and Mark Austin Wagoner
Co-founders, NutraHacker, LLC

Hey there nutrahackers,

We hope you have started the process of getting your WGS data. If not, don't delay! We have something amazing in process... here is some encouragement:

Up to Black Friday, all reports are 50% off! If you don't have WGS data yet, you can order the microarray version of the report and upload your WGS data when it is available. Upon getting WGS data, any previously purchased microarray reports can be upgraded to their WGS versions, meaning:

• A more comprehensive and in-depth nutrition report
• A higher resolution depression report
• The Celiac report will become a full HLA report
• And most significantly in the near future: true pharmacogenetics as the long-promised holy grail of personalized genetics, giving you the ability to get a look into how your body process es all the major and common pharmaceuticals.

Does a particular drug make you feel terrible? You will be able to find out why. 95% of people are deficient in at least one liver enzyme, 80% of people in at least two! Knowing this information will enable you to steer away from the wrong medications.

If you haven't yet started working on getting your WGS data, check out Sequencing.com, Nebula.org, or Dante Labs. What we will all be able to learn with NutraHacker will be breathtaking. It all begins with getting your whole genome sequenced.

Don't forget to take advantage of our Black Friday 50% off sale by accessing the NutraHacker Store using the link below:

Access the NutraHacker Black Friday Sale!

To your health,

Dr. Jon Vinea and Mark Austin Wagoner
Co-founders, NutraHacker, LLC

Dear fellow nutrahacker,

Very exciting developments to personalized genetics are in process!

In our most recent correspondence, we gave an update on the projects NutraHacker has been working on. At this time, we are pleased to announce the release of Critical Genetics based on the whole genome. These are the genes and conditions selected by the ACMG for high penetrance and actionability. Actionability has always been a primary goal of NutraHacker and is something everyone hopes to see when analyzing their genomes. In fact, this is where the name NutraHacker comes from! Actionability of your genetics with regards to nutrition.

Penetrance, generally defined, is the proportion of people that have a noticeable sign of a genetic variation, whether directly noticeable or via some sort of clinical testing. Some of these important variations might be found within programs like Promethease, but which are they? With our latest Critical Genetics report they are sifted out, every single one is important to know, and many more locations are analyzed.

To illustrate how important it is to move to whole genomes, our previous Critical Genetics looks at 46 snps, and now it is a staggering 13,809 locations! Many of these are quite rare, and it is unlikely that you would ever get that information without WGS. If you have purchased the previous microarray based Critical Genetics report but now have your WGS data ready, it is only $20 to process and receive an upgraded report. This is only for purchases prior to the release of the Critical Genetics WGS report. All future updates are included. At present, the report is limited to SNVs (single nucleotide variations) and will soon be updated with insertions and deletions- thousands more variations!

The price of the Critical Genetics for WGS will be set at $395, however for the first week only it will be available for $195. If you do not have your WGS and want to order the Critical Genetics for WGS, we will accept preorders at the $195 price and process your data when it is ready.

Find out more about securing the preorder of your Whole Genome Sequencing (WGS) Critical Genetics Report below:

Click here to find out more about the special one-time offer

Some of the more widely used services that do whole genome sequencing are:

• Nebula Genomics
• Sequencing.com
• Dante Labs
• WeGene

We highly encourage getting your WGS data, the potential of how you can use the information to improve your health is vastly increased over the previous microarray data. We are steadily working to add technologies that will utilize this potential and give clear, understandable, and digestible information. Our next project is a comprehensive liver enzyme analysis, the Pharmacogenetics (PGx) report. There are some services that currently do PGx testing, but nothing like what can be done with the whole genome.

Sincerely,

Mark Austin Wagoner and Dr. Jon Vinea
Co-founders, NutraHacker, LLC

Dear providers, practitioners, and health aficionados,

Over the past decade, we have been thrilled to provide useful genetic analysis for biohackers worldwide, expanding our offerings and depth of reporting. These reports have been amazing in helping users dial in their nutrition, health and fitness. Thus far it has been achieved using SNP microarray data offered from companies such as Ancestry and 23andMe. Those gave a useful, but limited, snapshot of an individual’s genetics, covering less than one percent of the human genome. They reported on common human variations, but not rare mutations.

To glean more out of the data, we first incorporated impute -using statistics to increase the size of those reports from hundreds of thousands to millions of datapoints. We then introduce d phasing to the market- pinpointing a variation to a specific gene copy. Phasing is tremendously useful, for instance if a gene has two different snps that break function, with phasing it c an be determined whether they are on different gene copies (gene completely non functional), or on the same gene copy (one working copy is present).

As far as we know, we are the only existing genetics analysis service that provides impute and phasing.

Very recently, the price of Whole Genome Sequencing (WGS) has decreased to below the $1000 mark. The NutraHacker homepage will soon have a running tally of prices of various WGS services and we strongly encourage everyone to get their WGS data. These services send you a kit with an easy cheek swab. We recommend the deepest sequencing that is accessible to you because it improves accuracy on ultra-rare mutations.

At the end of July, we began accepting WGS data in BAM or CRAM format to take full advantage of the increase from millions to billions of SNPs. This ends the pesky problem of unavailable snps. Impute is irrelevant to whole genomes, but NutraHacker will soon provide phasing of WGS data- a monumental improvement in the power of your genetic information.

Our first upcoming release exclusive to WGS data is the Critical Genetics report based on the full human genome. The critical genetics are the conditions and genes selected by the American College of Medical Genetics (no affiliation) that everyone should absolutely know about because they are actionable. The transition to WGS data has increased the amount of critical datapoints we can look at from approximately 85 (with impute) to over 14,000!

How is this different from Promethease? Promethease is at present limited to microarray chip data and not WGS. It reports on every disease and condition, however the information is provided in terms of relative risk and is non actionable. Too much information is presented, hiding the gems.

How are we able to look at a full genome without being overwhelming? Because these very important mutations are rare, you won't see too many of them, making this report digestible. Instead of risk ratios, you can learn WHAT the risk is and WHAT TO DO. This knowledge might have a drastic effect on your health- definitely something to show your physician.

Stay tuned for:

• The most complete, comprehensive liver panel ever made, including pharmaceutical alerts.
• An updated fitness report that predicts talent in different sports.
• A report that details how well you respond to minoxidil.
• More interactive report viewing

Is there anything you would like to see? Let us know!

These advancements are technical as well as computationally challenging and are not the types of reports you would find within 23andMe, Nebula, or any of our competitors. As we continue to add technologies not seen outside of the research community to personalized genetics, you may expect to see more communication and education coming from NutraHacker. If you have already purchased previous reports using your micro-array (23andMe etc.) data, upgrading your reports with your WGS data (from a company such as Nebula or Sequencing) will be possible for a small one-time processing fee of $20.