Newsletter
Dear nutrahacker,
We are reaching out to share some exciting insights into our latest advancements in HLA typing and its significant implications for pharmacogenetics and allergy susceptibility. At NutraHacker, we are committed to leveraging cutting-edge genetic insights to enhance personal health and wellness, and understanding your HLA status is a key part of this journey.
HLA Typing Now Included in PharmaShield Panel
We understand the importance of personalized healthcare. That's why we've expanded our pharmacogenetics panel to include Human Leukocyte Antigen (HLA) typing. The HLA system is a group of genes on chromosome 6 that code for proteins present on the surfaces of cells that are crucial for the immune system's recognition of foreign substances.
This addition comes at no extra charge and offers a deeper dive into how your genetic makeup can influence your body's response to medications. HLA typing is a powerful tool in pharmacogenomics, helping to identify potential drug sensitivities and guiding more personalized medication choices. This update aims to enhance medication safety and efficacy, tailored just for you.
Stevens-Johnson Syndrome (SJS) is a rare, serious disorder of the skin and mucous membranes (we strongly recommend you don't google images). It's usually a reaction to a medication or an infection. SJS is considered a medical emergency that requires hospitalization.
SJS is thought to be a type of hypersensitivity reaction, with genetics playing a role in the body's reaction to medication. Certain HLA types have been associated with an increased risk of developing SJS when exposed to specific medications.
For example, the HLA-B*1502 allele has been linked to a higher risk of SJS when individuals take certain anticonvulsant drugs. The reaction involves the activation of the body's immune system in a harmful way, leading to severe inflammation and cell death in the skin and mucous membranes.
Prevention involves avoiding the use of medications that have previously triggered SJS in the patient or avoiding drugs known to be high risk if the patient has a known genetic predisposition (e.g., carrying the HLA-B*1502 allele and avoiding certain anticonvulsants if of Asian descent). Because of the association between certain medications and SJS, genetic testing for specific HLA alleles before starting certain treatments can be an important preventive measure, reducing the risk of this severe reaction.
Upcoming: Mold and Food Allergies Insights
Our commitment to your health doesn't stop there. We're excited to announce that we will soon provide updates regarding mold and food allergies, directly linked to your HLA status. This forthcoming feature will offer valuable insights into potential allergy predispositions, enabling you to make informed decisions about your diet and environment. Stay tuned for this update, as we work diligently to bring you the latest in genetic health insights.
Last Chance: Take Advantage of Our Sale Before It Ends on February 29th!
As a reminder, our current sale is quickly coming to a close. If you've been considering deepening your understanding of your genetic profile or sharing the gift of health with others, now is the perfect opportunity. You can order without currently having your Whole Genome Sequencing (WGS) data ready, but you will eventually need your WGS data to access the PharmaShield and HLA panel. This sale ends on February 29th, so don't miss out on the chance to take advantage of our exclusive offers, available below:
Click here to Access the Initial Release Sale, Ending Soon
At NutraHacker, your health and satisfaction are our top priorities. We are here to support your journey towards optimal wellness with cutting-edge genetic insights. If you have any questions about your panel, our new features, or how to make the most of our current sale, please don't hesitate to reach out.
Thank you for choosing NutraHacker. We look forward to continuing to serve your health and wellness needs.
Warm regards,
Dr Jonathan Vinea and Mark Austin Wagoner
Co-founders, NutraHacker, LLC
P.S. On a different note, HLA typing opens up fascinating possibilities in the realm of genetic dating. The diversity of the HLA genes plays a role in natural attraction, with some studies suggesting that individuals may be subconsciously attracted to potential partners with dissimilar HLA types. This genetic diversity is believed to contribute to a healthier offspring immune system.
We're thrilled to share some groundbreaking news from NutraHacker that's set to enhance your approach to wellness: Introducing NutraPedia - The Journal Club has been renamed and evolved into your gateway to evidence-based supplement knowledge, available for FREE and with NO account required! In our quest to empower your health journey, we've leveraged the latest in AI technology to sift through and summarize the most credible, science-backed research on over 400 supplements. With NutraPedia, reliable insights into your health regimen are now at your fingertips, hassle-free. Have you ever wondered about the real benefits of Curcumin, or if Echinacea truly boosts your immune system? NutraPedia provides clear, accessible summaries and direct links to original research, ensuring you're well-informed to make the best health decisions. This groundbreaking resource is designed to demystify supplement science for everyone - no subscriptions, no barriers. Just pure, accessible knowledge to support your wellness goals. Click here to start exploring NutraPedia and embrace the clarity and confidence in your supplement choices. We're incredibly excited to offer this valuable resource to you at no cost. It's our way of reaffirming our commitment to your health and wellness journey. Thank you for being an integral part of the NutraHacker community. Together, let's navigate the path to wellness with informed, empowered steps. Best wishes, The NutraHacker Team
Why Explore NutraPedia?
Your Trusted Resource for Supplement Science
Dive Into the Science – No Strings Attached
Dear NutraHackers,
The True Detox and PharmaShield PGx Panel has been updated to include CYP2D6 and other genes.
CYP2D6 is a major gene that metabolizes about 25% of prescription medications. Reacting poorly to a medication might be due to non-functional CYP2D6.
Besides breaking down drugs, liver enzymes sometimes activate them. Prodrugs are drugs that are inactive until our metabolism activates them. If we are lacking an enzyme that activates a prodrug, then the drug might be ineffective and/or have increased side effects.
CYP2D6 activates drugs like codeine (prodrug for morphine), dextromethorphan (DXM, ingredient in cough syrup), and ketamine (important for the studies using ketamine to treat depression). It also converts the SNRI depression medication venlafaxine (USA prescription rank 47th place) to its active form desvenlafaxine. If medications like codeine or DXM have made you feel terrible, CYP2D6 might be the reason why.
CYP2D6 also detoxifies multiple pesticides and fungicides, such as organophosphate, organochlorine, fipronil and carbendazim. Besides CYP2D6, the update also includes several new genes, bringing total coverage to the following list:
| ABCG2 | CACNA1S | CFTR |
| CYP1A1 (new addition) | CYP1A2 (new addition) | CYP2A6 (new addition) |
| CYP2B6 | CYP2C19 | CYP2C8 (new addition) |
| CYP2C9 | CYP2D6 (new addition) | CYP2E1 (new addition) |
| CYP3A4 | CYP3A5 | CYP4F2 |
| CYPOR (new addition) | DPYD | F5 |
| G6PD | GSTM1 (new addition) | IFNL3 |
| NAT1 (new addition) | NUDT15 | RYR1 |
| SLCO1B1 | TPMT | UGT1A1 |
| VKORC1 |
The True Detox and PharmaShield (PGx) Panel needs whole genome sequencing (WGS) raw data and will not work with 23andMe or Ancestry. It is worth it to get whole genome sequencing data if you do not currently have it. CYP2D6 is highly polymorphic and therefore needs WGS data to accurately assess what configuration each individual has.
To help you deepen your understanding of genes fundamental to detoxification and pharmacogenetics, we recently released our first book on Kindle, NutraHacker's Guide to Pharmacogenetics.
Our next projects will be to update the Journal Club with useful studies so that you can look up the useful research on just about every supplement (for free) and also completing an Human leukocyte antigen (HLA) panel. HLA has applications for knowing if there’s a risk for severe reactions to medications, organ donor matching, and even dating!
Sincerely,
Dr. Jon Vinea and Mark Austin Wagoner
Co-founders, NutraHacker, LLC
Hey there nutrahacker,
This December NutraHacker had its 10th birthday!
Since starting in 2013 we have grown in leaps and bounds, adding many more reports, expanding microarray data with imputation, processing whole genome sequencing raw data and recently launching our True Detox and PGx Panel. It has been quite the journey!
To commemorate turning 10, we will be offering a 50% off discount until Jan 1st, 2024. Use the coupon code 'NUTRA10Y' at checkout to take advantage.
To your health,
Dr. Jon Vinea and Mark Austin Wagoner
Co-founders, NutraHacker, LLC
Dear NutraHackers,
Did you know that the True Detox and PharmaShield (PGx) Panel is also a detoxification panel!? That's why we changed the name from Pharmacogenetics Panel. Looking at the diplotype summary table will help determine how these extremely important enzymes function overall.
Here are some natural and common toxins and the liver enzymes that detoxify them. If you have decreased function on any of these enzymes, you won’t detoxify them as well. Also, if you have increased enzyme function, you will detoxify them extra rapidly!
Updates to include natural compounds and toxins are on the way- much like our original free detoxification report but again in much more detail due to using WGS (Whole Genome Sequencing) data.
Our True Detox and PharmaShield (PGx) panel has been updated to add 1,028 new drugs to metabolic analysis! This includes significant additions such as Levothyroxine, Amlodipine, Losartan, Montelukast and Trazodone.
This panel can be a daunting tool to use, here are a couple tips to try out:
Select: under Gene Activity [non normal], and under Data Source [International and Dutch consortiums] and [FDA] groups to see published specific recommendations for your genetics. The links in the table go into much more depth, definitely check them out!
If a particular drug that you have taken in the past has made you feel terrible, try searching for the generic drug name and see if there is a genetic explanation in your liver enzymes (CYP2D6 is a big one and will be available soon).
Sincerely,
Dr. Jon Vinea and Mark Austin Wagoner
Co-founders, NutraHacker, LLC
Dear NutraHackers,
We're beyond excited to share a groundbreaking development in personalized healthcare – the launch of NutraHacker's True Pharmacogenetics (PGx) Panel for Whole Genome Sequencing (WGS)!
Why It's a Game-Changer:
For years, the dream of personalized genetics seemed just out of reach. Now, it's not just a dream – it's reality. Our True PGx Panel isn't just another product; it's a leap into the future of personalized health care.
What Makes Our PGx Panel Unique?
Continuous Evolution & Mobile-Friendly Access
We're committed to continuously enhancing the WGS PGx panel. Stay tuned for broader gene and Rx coverage. Plus, a mobile-friendly version is coming soon - perfect for on-the-go consultations!
Accessible Subscription Model
In our mission to make this revolutionary tool widely accessible, we're introducing an affordable subscription model, ensuring you always have the latest updates.
Special Preorder Offer!
Curious to learn more? Secure your preorder of the Whole Genome Sequencing (WGS) True Pharmacogenetics (PGx) Panel at an exclusive initial release price:
Click here to find out more about the initial release offer, with a free gift inside
Recommended WGS Services
If you're new to whole genome sequencing, here are some trusted services to get started:
- Nebula Genomics
- Sequencing.com
- Dante Labs
- WeGene
Don't miss this chance to embark on a journey of personalized healthcare like never before!
Sincerely,
Dr. Jon Vinea and Mark Austin Wagoner
Co-founders, NutraHacker, LLC