Gene IL13
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Also known as
IL-13, P600, interleukin 13Overview
IL13 (Interleukin 13) encodes a cytokine that is closely related to IL-4 and shares many of its functions in type 2 immune responses and allergic inflammation. IL-13 is produced by activated T cells, mast cells, basophils, eosinophils, and innate lymphoid cells and plays critical roles in airway inflammation and mucus production.IL-13 is particularly important in asthma pathophysiology, where it promotes airway hyperresponsiveness, goblet cell hyperplasia, mucus secretion, and fibrosis. The R130Q polymorphism (rs20541) in IL13 is associated with increased asthma risk and elevated IgE levels. IL-13 also contributes to atopic dermatitis and other allergic conditions.
Understanding your IL13 genetic status helps assess risk for allergic airway diseases. IL-13 is a therapeutic target, with lebrikizumab and tralokinumab (IL-13 blockers) showing efficacy in treating asthma and atopic dermatitis. This genetic information can inform personalized approaches to managing allergic conditions.