Also known as
NR1I1, PPP1R163
Overview
The VDR (Vitamin D Receptor) gene encodes a protein called the vitamin D receptor, which is a member of the nuclear hormone receptor family. The VDR protein plays a key role in the body's utilization of calcium and phosphorus, as well as in the immune system. The VDR is activated by vitamin D, which is converted from 7-dehydrocholesterol in the skin when exposed to UVB radiation. Activated VDRs then bind to specific DNA sequences called vitamin D response elements, leading to the transcription of target genes. Dysregulation of the VDR pathway has been linked to a variety of diseases, including cancer, osteoporosis, and autoimmune disorders.
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