Histamine/Allergy Panel Report Description



The most comprehensive genetic report on histamine intolerance and allergies available on the market today for your raw DNA data.

NutraHacker reports mutations (single nucleotide polymorphisms) in the uploaded genome. Genes not reported in this report are either normal, not actionable, or not currently detected by NutraHacker. Mutations whose RSID has an asterisk (*) have been imputed. The expected allele is the one seen in a normally functioning gene. The high-risk alleles reported are the ones measured from the uploaded genome. NutraHacker reports the effects of these mutations as discovered by published empirical data and suggests nutritional supplements that can mitigate potential issues caused by these mutations.

Importantly, the Histamine/Allergy Panel goes beyond just SNP-level reporting—it also calculates overall gene functionality based on cumulative genetic variation. This provides a more complete picture of how key histamine-related genes are working (or not working) in your body, even when no single SNP tells the full story.

This report is meant to serve as a guide for nutritional supplementation for the owner of the genome and is not applicable to any other individual. Supplement quantities and dosages are not included as they are indicated on the purchased product. Multiple recommendations for the same supplement does not mean that the dosage should be multiplied. In the case of a conflict (such as a particular vitamin being both encouraged and discouraged), the owner of the genome should assess his/her own personal biology to decide whether to include or discard that particular supplement. Please see our FAQ for advice on conflicts.

Histamine is a natural compound in your body that helps fight off invaders—but when it’s out of balance due to genetic variations, it can trigger a cascade of issues like sneezing, itching, headaches, bloating, or even brain fog. The NutraHacker Histamine/Allergy Panel analyzes 39 genes tied to histamine processing, giving you a clear picture of how your body handles this powerful molecule—not just at the SNP level, but at the gene functionality level as well.

Imagine finally understanding why you react the way you do—and having a roadmap to feel better that starts now and keeps getting better with future updates. Our cutting-edge genetic test decodes your DNA to reveal the root causes of your symptoms and provides actionable, science-backed strategies to take back control.

The genes analyzed in the Histamine/Allergy Panel include:

  1. ABCC2: Encodes MRP2, a transporter that may indirectly influence histamine levels by affecting drug and toxin clearance, potentially exacerbating allergic responses in conditions like Dubin-Johnson syndrome.
  2. ALDH1B1: Involved in aldehyde metabolism; variants can impair detoxification of histamine metabolites, contributing to histamine buildup and intolerance symptoms like allergies.
  3. ALDH2: Key enzyme in breaking down histamine-derived acetaldehyde; deficiencies lead to histamine accumulation, flushing, and heightened allergic reactions, especially with alcohol.
  4. AOC1: Encodes DAO, the primary enzyme degrading extracellular histamine; polymorphisms reduce activity, increasing histamine levels and risk of allergies, migraines, and GI issues.
  5. COMT: Degrades catecholamines but interacts with methylation pathways; slow variants impair histamine breakdown via HNMT, promoting inflammation and allergic responses.
  6. FCER1A: Encodes the alpha subunit of the high-affinity IgE receptor on mast cells; variants enhance IgE binding, triggering histamine release and amplifying allergic reactions.
  7. FLG: Mutations cause skin barrier defects, increasing allergen penetration and susceptibility to atopic dermatitis, hay fever, and food allergies via enhanced histamine-mediated inflammation.
  8. GATA2: Transcription factor regulating HDC expression in mast cells; deficiency reduces histamine synthesis but impairs immune responses, altering allergy progression.
  9. GPR65: Proton-sensing receptor on immune cells; influences pH-dependent inflammation, potentially modulating histamine release in acidic allergic microenvironments.
  10. HDC: Encodes histidine decarboxylase, essential for histamine synthesis; variants affect histamine production in mast cells, directly impacting allergic reactions and anaphylaxis.
  11. HNMT: Encodes histamine N-methyltransferase, degrading intracellular histamine; polymorphisms reduce activity, leading to elevated levels and worsened allergic symptoms like asthma.
  12. HRH1: Histamine H1 receptor mediating allergic responses like itching and bronchoconstriction; variants increase sensitivity, exacerbating hay fever, urticaria, and anaphylaxis.
  13. HRH2: H2 receptor involved in gastric acid secretion and immune modulation; influences Th2 responses, contributing to allergic inflammation and airway hyperreactivity.
  14. HRH3: Primarily presynaptic autoreceptor in CNS; modulates neurotransmitter release, indirectly affecting peripheral allergic responses via neural-immune crosstalk.
  15. HRH4: H4 receptor on immune cells promotes cytokine release and chemotaxis; key in Th2-driven allergies, asthma, and dermatitis by enhancing histamine-mediated inflammation.
  16. IL10: Anti-inflammatory cytokine suppressing Th2 responses; low production variants heighten histamine-driven allergies by failing to dampen IgE and eosinophil activation.
  17. IL13: Drives mucus production and airway hyperreactivity; synergizes with histamine to amplify allergic asthma and dermatitis via STAT6 signaling.
  18. IL1B: Pro-inflammatory cytokine enhancing mast cell degranulation; promotes histamine release and sustains chronic allergic inflammation in airways and skin.
  19. IL3: Supports mast cell growth and histamine release; variants increase basophil/mast cell activity, heightening immediate allergic responses.
  20. IL33R: Receptor for IL-33, an alarmin activating ILC2s and mast cells; drives type 2 inflammation, eosinophilia, and histamine-mediated allergies like asthma.
  21. IL4: Promotes IgE production and Th2 differentiation; enhances histamine receptor expression, intensifying allergic symptoms in rhinitis and eczema.
  22. IL6: Induces acute inflammation and B-cell IgE switching; histamine stimulates IL-6 via H1R, perpetuating allergic cascades in rhinitis and asthma.
  23. KIT: Receptor for stem cell factor on mast cells; mutations alter mast cell survival and degranulation, influencing histamine release in allergies.
  24. MAOA: Degrades methylated histamine; slow variants cause buildup, worsening histamine intolerance and allergic symptoms like hives and rhinitis.
  25. MAOB: Metabolizes histamine derivatives; deficiencies impair clearance, contributing to elevated histamine and chronic allergic inflammation.
  26. MS4A2: Beta chain of IgE receptor; variants enhance signaling, increasing mast cell histamine release and allergy severity in asthma and atopy.
  27. MTHFR: Impairs methylation for HNMT activity; mutations elevate histamine, linking to allergies, migraines, and Th2-driven inflammation.
  28. NLRP3: Inflammasome activating IL-1β; triggers mast cell pyroptosis and histamine release, amplifying allergic rhinitis and anaphylaxis.
  29. PEMT: Supports cell membrane stability for mast cells; variants increase degranulation and histamine release, promoting allergic responses.
  30. PTGDS: Produces PGD2, amplifying Th2 inflammation; synergizes with histamine in mast cell activation during allergic asthma and rhinitis.
  31. PTGES: Synthesizes PGE2, modulating inflammation; enhances histamine effects in pain and fever during allergic reactions.
  32. PTGS1: COX-1 isoform producing prostaglandins; influences baseline inflammation, indirectly sustaining histamine-mediated allergies.
  33. PTGS2: Inducible COX-2; drives PGE2 in allergic inflammation, exacerbating histamine-induced airway hyperreactivity and edema.
  34. SLC22A3: Transports histamine for clearance; variants impair uptake, leading to prolonged exposure and worsened allergic symptoms.
  35. SLC22A4: Organic cation transporter; affects histamine uptake in immune cells, influencing allergic inflammation in rhinitis and asthma.
  36. STAT6: Transduces IL-4/IL-13 signals for Th2 responses; variants enhance IgE and eosinophilia, amplifying histamine-driven allergies.
  37. TMEM79: Maintains skin barrier; mutations cause atopic dermatitis, increasing allergen penetration and histamine-mediated itch.
  38. TPMT: Methylates thiopurines; interacts with methylation for histamine degradation, variants indirectly affecting allergic drug responses.
  39. TRPV1: Ion channel sensitized by histamine; mediates itch and pain in allergies via PLA2/LOX pathway activation.
The NutraHacker Histamine Panel is accessible exclusively via the NutraHacker App. Upload raw DNA data to get your very own personalized Histamine/Allergy Panel at the NutraHacker Store.