Gene MAO-A

Also known as

monoamine oxidase A, MAOA, amine oxidase flavin-containing A

Overview

MAO-A (Monoamine Oxidase A) encodes a mitochondrial enzyme that degrades monoamine neurotransmitters including serotonin, norepinephrine, and dopamine. This enzyme is critical for regulating neurotransmitter levels in the brain and is a major target for antidepressant medications (MAO inhibitors). MAO-A is also important for metabolizing dietary amines like tyramine.

A functional polymorphism in the MAO-A promoter (MAOA-uVNTR) affects enzyme activity levels. Low-activity variants have been associated with increased impulsivity and aggressive behavior, particularly in males who experienced childhood adversity. This gene-environment interaction has been extensively studied in behavioral genetics. High-activity variants may influence susceptibility to depression and anxiety.

Understanding your MAO-A genetic status provides insights into neurotransmitter metabolism and behavior. This information is relevant for understanding mood regulation, stress responses, and potentially response to MAO inhibitor medications. The gene's location on the X chromosome means males have only one copy.

NutraHacker Raw DNA Analysis Products that include this gene

• Complete Mutation Nutrition Report
• Histamine/Allergy Panel

Upload raw DNA data to get your very own analysis of gene MAO-A through your personalized DNA reports.