Gene MAO-B

Also known as

monoamine oxidase B, MAOB, amine oxidase flavin-containing B

Overview

MAO-B (Monoamine Oxidase B) encodes a mitochondrial enzyme that preferentially degrades phenylethylamine and dopamine, with lower activity toward serotonin and norepinephrine compared to MAO-A. MAO-B is the predominant form in the brain, particularly in glial cells, and its activity increases with age. This enzyme is a therapeutic target in Parkinson's disease.

MAO-B inhibitors like selegiline and rasagiline are used to treat Parkinson's disease by preventing dopamine breakdown and providing neuroprotection. Genetic variants affecting MAO-B activity may influence susceptibility to Parkinson's disease and response to treatment. The enzyme also metabolizes neurotoxins like MPTP that can cause parkinsonism.

Understanding your MAO-B genetic status provides insights into dopamine metabolism and neurological health. This information is relevant for understanding Parkinson's disease risk and may inform treatment decisions for dopamine-related disorders. Like MAO-A, MAO-B is located on the X chromosome.

NutraHacker Raw DNA Analysis Products that include this gene

• Complete Mutation Nutrition Report
• Histamine/Allergy Panel

Upload raw DNA data to get your very own analysis of gene MAO-B through your personalized DNA reports.