Gene HNMT

Also known as

HMT, histamine N-methyltransferase

Overview

HNMT (Histamine N-Methyltransferase) encodes the enzyme responsible for the intracellular degradation of histamine through N-methylation. Unlike diamine oxidase (DAO) which breaks down extracellular and dietary histamine, HNMT is the primary pathway for metabolizing histamine within cells, particularly in the brain and airways.

HNMT plays a crucial role in regulating histamine levels in the central nervous system, where histamine acts as a neurotransmitter affecting arousal, attention, and cognitive function. Genetic variants that reduce HNMT activity can lead to increased histamine levels and have been associated with allergic conditions, asthma, and potentially neurological symptoms including sleep disturbances and anxiety.

The combination of reduced HNMT and DAO activity can significantly impair overall histamine clearance, leading to more pronounced histamine intolerance symptoms. Understanding your HNMT genetic status, alongside DAO, provides a comprehensive picture of your histamine metabolism capacity and can guide dietary and lifestyle interventions.

NutraHacker Raw DNA Analysis Products that include this gene

• Histamine/Allergy Panel

Upload raw DNA data to get your very own analysis of gene HNMT through your personalized DNA reports.