Also known as
G protein-coupled receptor 65, TDAG8, T-cell death-associated gene 8
Overview
GPR65 (G Protein-Coupled Receptor 65), also known as TDAG8, is a gene that encodes a proton-sensing G protein-coupled receptor activated by acidic pH. This receptor plays important roles in immune regulation, inflammation, and cellular responses to acidosis. GPR65 is expressed in various immune cells including T cells, macrophages, and dendritic cells, where it modulates immune responses in acidic microenvironments such as inflamed tissues and tumor sites. Activation of GPR65 by low pH can suppress inflammatory responses and regulate T cell function. The receptor has been implicated in inflammatory bowel disease, with genetic variants associated with disease risk. GPR65 also plays a role in bone homeostasis, kidney function, and potentially in cancer biology where acidic tumor microenvironments may influence immune cell behavior. Understanding GPR65 variants may provide insights into immune function, inflammatory conditions, and responses to acidic environments in various tissues.
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