Gene PTGDS

Also known as

prostaglandin D2 synthase, lipocalin-type PGDS, L-PGDS, beta-trace protein

Overview

PTGDS (Prostaglandin D2 Synthase) encodes an enzyme that catalyzes the production of prostaglandin D2 (PGD2) from prostaglandin H2. PGD2 is involved in sleep regulation, temperature control, and allergic inflammation. PTGDS is also known as beta-trace protein and is found in cerebrospinal fluid, where it may serve as a marker for CSF leaks.

In the context of histamine and allergy, PGD2 is a major mediator released by mast cells during allergic reactions. It contributes to allergic symptoms including bronchoconstriction, vasodilation, and eosinophil recruitment. Variants affecting PTGDS activity may influence susceptibility to allergic diseases and the severity of allergic responses.

Understanding your PTGDS genetic status provides insights into prostaglandin metabolism and allergic inflammation. This information is relevant for understanding allergic disease susceptibility, sleep regulation, and potentially response to medications targeting prostaglandin pathways.

NutraHacker Raw DNA Analysis Products that include this gene

• Histamine/Allergy Panel

Upload raw DNA data to get your very own analysis of gene PTGDS through your personalized DNA reports.