Gene HRH1
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Also known as
H1R, histamine receptor H1Overview
HRH1 (Histamine Receptor H1) encodes the histamine H1 receptor, a G protein-coupled receptor that mediates many of the classic symptoms of allergic reactions. When histamine binds to H1 receptors, it triggers itching, hives, nasal congestion, bronchoconstriction, and increased vascular permeability leading to swelling and redness.H1 receptor activation is responsible for the immediate symptoms of allergic reactions and is the primary target of antihistamine medications like diphenhydramine, cetirizine, and loratadine. H1 receptors are found throughout the body including the smooth muscle, endothelium, and central nervous system, where they also play roles in the sleep-wake cycle and cognitive function.
Genetic variants in HRH1 may influence individual responses to histamine and the effectiveness of antihistamine medications. Understanding your HRH1 genetic status, combined with knowledge of histamine-metabolizing enzyme variants, provides a comprehensive picture of your histamine sensitivity and allergy predisposition.