Gene HRH3
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Also known as
histamine H3 receptor, GPCR97, HH3ROverview
HRH3 (Histamine Receptor H3) encodes the histamine H3 receptor, a presynaptic G protein-coupled receptor predominantly expressed in the central nervous system. Unlike other histamine receptors, H3R functions primarily as an autoreceptor and heteroreceptor, regulating the release of histamine and other neurotransmitters including acetylcholine, dopamine, norepinephrine, and serotonin.The H3 receptor plays important roles in cognition, sleep-wake regulation, appetite control, and neuroinflammation. H3R antagonists are being developed as potential treatments for narcolepsy, ADHD, Alzheimer's disease, and obesity. Variants in HRH3 have been associated with differences in cognitive function and sleep patterns.
Understanding your HRH3 genetic status provides insights into central nervous system histamine signaling and its effects on cognition, alertness, and appetite regulation. This information may be relevant for understanding individual responses to histaminergic medications and susceptibility to related disorders.