Gene PTGES
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Also known as
prostaglandin E synthase, microsomal PGES-1, mPGES-1Overview
PTGES (Prostaglandin E Synthase) encodes microsomal prostaglandin E synthase-1, an inducible enzyme that converts prostaglandin H2 to prostaglandin E2 (PGE2). PGE2 is a major pro-inflammatory mediator involved in pain, fever, and inflammation. PTGES is functionally coupled with COX-2 and is upregulated during inflammation.PTGES is a therapeutic target for inflammatory conditions because inhibiting this enzyme could reduce PGE2 without affecting other prostaglandins. Genetic variants affecting PTGES expression or activity may influence susceptibility to inflammatory diseases and response to anti-inflammatory treatments. PGE2 also plays roles in cancer progression and immune modulation.
Understanding your PTGES genetic status provides insights into prostaglandin E2 production and inflammatory responses. This information is relevant for understanding pain sensitivity, inflammatory disease susceptibility, and potentially response to anti-inflammatory medications targeting prostaglandin pathways.