Gene HRH2
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Also known as
histamine H2 receptor, gastric histamine receptorOverview
HRH2 (Histamine Receptor H2) encodes the histamine H2 receptor, a G protein-coupled receptor primarily expressed in gastric parietal cells, cardiac tissue, and smooth muscle. Activation of this receptor stimulates gastric acid secretion, increases heart rate, and modulates immune cell function.H2 receptor blockers (like ranitidine and famotidine) are widely used to treat acid reflux and peptic ulcers by blocking histamine's ability to stimulate gastric acid production. Variants in HRH2 may influence susceptibility to gastric disorders, response to H2 blocker medications, and potentially cardiac responses to histamine.
Understanding your HRH2 genetic status provides insights into gastric acid regulation and histamine response in the stomach and heart. This information is relevant for understanding digestive health, medication response, and histamine-related conditions.