Gene HRH4
Back to Curriculum
Also known as
histamine H4 receptor, GPCR105, GPRv53Overview
HRH4 (Histamine Receptor H4) encodes the histamine H4 receptor, the most recently discovered histamine receptor. H4R is primarily expressed on immune cells including mast cells, eosinophils, dendritic cells, and T lymphocytes, where it modulates inflammatory and immune responses.The H4 receptor plays key roles in chemotaxis of immune cells, pruritus (itching), and allergic inflammation. H4R antagonists are being developed as novel treatments for allergic rhinitis, asthma, atopic dermatitis, and inflammatory bowel disease. Variants in HRH4 have been associated with atopic dermatitis and other allergic conditions.
Understanding your HRH4 genetic status provides insights into immune cell responses to histamine and susceptibility to allergic and inflammatory conditions. This information is particularly relevant for understanding itching, allergic disease severity, and potential response to H4R-targeted therapies.