Gene ABCC2
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Also known as
MRP2, CMOAT, DJS, cMRPOverview
ABCC2 (ATP Binding Cassette Subfamily C Member 2) encodes a protein called multidrug resistance-associated protein 2 (MRP2), which is an important membrane transporter. MRP2 is primarily expressed in the liver, kidney, and intestine, where it plays a crucial role in the elimination of drugs, toxins, and endogenous compounds from the body.MRP2 transports a wide variety of substrates including bilirubin glucuronides, glutathione conjugates, and various drugs. Mutations in ABCC2 are associated with Dubin-Johnson syndrome, a rare inherited disorder characterized by chronic conjugated hyperbilirubinemia. In the context of histamine metabolism, MRP2 may indirectly influence histamine levels by affecting the clearance of histamine metabolites and drugs that interact with histamine pathways.
Genetic variations in ABCC2 can affect drug pharmacokinetics and may contribute to individual differences in drug response and toxicity. Understanding your ABCC2 status can help optimize medication choices and dosing strategies.