What Are SNPs?
Single Nucleotide Polymorphisms (SNPs, pronounced "snips") are the most common type of genetic variation. Each SNP represents a difference in a single DNA building block, called a nucleotide. These variations can influence how your body processes nutrients, responds to medications, and manages various biological functions.
Our comprehensive SNP guides explain what each variant means, how it may affect your health, and what nutritional and lifestyle strategies may be beneficial based on your genetic profile.
Methylation & Folate Metabolism
- MTHFR C677T (rs1801133) - The most researched methylation variant
- MTHFR A1298C (rs1801131) - Second major MTHFR variant
Neurotransmitter & Mental Health
- COMT Val158Met (rs4680) - Dopamine and stress response
- DRD2 Taq1A (rs1800497) - Dopamine receptor density
- BDNF Val66Met (rs6265) - Brain plasticity and mood
- OXTR (rs53576) - Oxytocin receptor and social bonding
- OPRM1 A118G (rs1799971) - Opioid receptor and reward
Cognitive Health & Longevity
- APOE e4 (rs429358) - Alzheimer's risk and lipid metabolism
Fitness & Athletic Performance
- ACTN3 R577X (rs1815739) - Muscle fiber type and power
- PPARG Pro12Ala (rs1801282) - Fat metabolism and insulin
- ADRB2 Arg16Gly (rs1042713) - Adrenaline response
Metabolism & Nutrition
- LCT/MCM6 (rs4988235) - Lactose tolerance
- TCF7L2 (rs7903146) - Type 2 diabetes risk
- APOA2 (rs5082) - Saturated fat response
- PON1 Q192R (rs662) - Antioxidant enzyme
Histamine Metabolism
- AOC1 Thr16Met (rs10156191) - DAO enzyme activity
- AOC1 Ser332Phe (rs1049742) - DAO and migraine
- AOC1 Promoter (rs2052129) - DAO expression
- HNMT Thr105Ile (rs1050891) - Brain histamine
- HNMT C314T (rs11558538) - Histamine methylation
- HRH1 (rs2241572) - H1 receptor
- HRH2 (rs2067474) - H2 receptor and gastric acid
Serotonin & Mood
- HTR2A T102C (rs6313) - Serotonin 2A receptor
- TPH1 A218C (rs1799913) - Serotonin synthesis
- SLC6A4 5-HTTLPR (rs4795541) - Serotonin transporter
- SLC6A4 rs25531 - 5-HTTLPR modifier
- ADRA2A (rs1800544) - Norepinephrine signaling
Vitamin D & Skin Health
- VDR Cdx2 (rs11568820) - Vitamin D receptor expression
- VDR FokI (rs2228570) - Vitamin D receptor structure
- VDR BsmI (rs1544410) - Vitamin D receptor stability
- GC (rs7041) - Vitamin D binding protein transport
- GC Thr436Lys (rs4588) - Vitamin D binding protein concentration
Collagen & Connective Tissue
- COL1A1 Sp1 (rs1800012) - Collagen production and skin aging
Inflammation & Immune
- TNF G-308A (rs1800629) - TNF-alpha and inflammation
- TNF G-238A (rs361525) - TNF-alpha and psoriasis risk
Detoxification
- GSTP1 Ile105Val (rs1695) - Glutathione conjugation
- GSTP1 Ala114Val (rs1138272) - Enzyme stability
Drug Metabolism (Pharmacogenetics)
- CYP2C9 *2 (rs1799853) - Warfarin and NSAID metabolism
- CYP2C9 *3 (rs1057910) - Severely reduced drug metabolism
- CYP2D6 *4 (rs3892097) - Codeine and antidepressant metabolism
- CYP1A2 *1F (rs762551) - Caffeine metabolism
Hormone Metabolism
- ESR2 (rs4986938) - Estrogen receptor beta
B12 & Methylation
- MTR A2756G (rs1805087) - Methionine synthase
- MTRR A66G (rs1801394) - B12 recycling
Diabetes & Metabolism
- TCF7L2 IVS3 (rs12255372) - Type 2 diabetes risk
Circadian Rhythm & Sleep
- CLOCK T3111C (rs1801260) - Chronotype and sleep patterns
Obesity & Appetite
- MC4R (rs17782313) - Appetite regulation
- FTO (rs9939609) - The obesity gene
- FTO (rs1558902) - BMI and weight risk
Carrier Status & Hereditary Conditions
- HBB (rs334) - Sickle cell trait
- BRCA1 5382insC (rs80357906) - Breast/ovarian cancer risk
- BRCA2 6174delT (rs80357713) - Breast/ovarian/prostate cancer risk
Iron Metabolism (Hemochromatosis)
- HFE H63D (rs1799945) - Iron absorption variant
- HFE C282Y (rs1800562) - Hereditary hemochromatosis
Get Your Genetic Analysis
Understanding your SNPs is just the first step. NutraHacker's reports analyze hundreds of genetic variants to provide personalized nutrition, supplement, and lifestyle recommendations based on your unique DNA.