Gene IRS1
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Also known as
insulin receptor substrate 1, HIRS-1Overview
IRS1 (Insulin Receptor Substrate 1) encodes a key signaling protein that mediates insulin and IGF-1 actions in cells. When insulin binds its receptor, IRS1 becomes phosphorylated and activates downstream pathways controlling glucose uptake, protein synthesis, and cell growth. It serves as the critical bridge between insulin/IGF-1 receptors and intracellular signaling cascades.Variants in IRS1 have been strongly associated with type 2 diabetes risk, insulin resistance, and metabolic syndrome. The Gly972Arg polymorphism impairs insulin signaling and is associated with reduced insulin sensitivity. IRS1 variants also influence body fat distribution, with some variants associated with preferential fat storage in the abdominal region.
Understanding your IRS1 genetic status provides insights into insulin sensitivity and metabolic health. This information is relevant for understanding diabetes risk, weight management challenges, and guiding dietary and lifestyle interventions for metabolic optimization.