Terminalia Arjuna Overview

1. Conditions Studied

Terminalia Arjuna has been studied for a variety of conditions, primarily those related to heart health. Such conditions include:

• Chronic stable angina
• Congestive heart failure
• Hypercholesterolemia
• Myocardial infarction recovery
• Hypertension

2. Efficacy in Treating Conditions

Research suggests that Terminalia Arjuna may be effective in treating certain heart ailments. For example:

• It has shown promise in reducing symptoms of angina and improving cardiac function in cases of congestive heart failure.
• It might help in lowering cholesterol levels and managing hypertension.

However, more rigorous clinical trials are needed to establish its efficacy conclusively.

3. Health Benefits

Terminalia Arjuna is believed to offer several health benefits, such as:

• Antioxidant properties
• Anti-inflammatory effects
• Potential reduction in the risk of atherosclerosis due to its hypocholesterolemic effect
• Cardioprotective qualities

4. Potential Downsides

While Terminalia Arjuna is generally considered safe, some potential downsides include:

• Gastrointestinal discomfort
• Potential interactions with other medications
• Insufficient data on its long-term safety

It is crucial to consult a healthcare provider before using Terminalia Arjuna, especially for individuals with pre-existing medical conditions or those taking other medications.

5. Impact on Genetic Variations

There is limited research on the interaction between Terminalia Arjuna and specific genetic variations. However, some studies suggest that genetic factors may influence an individual's response to herbal treatments. Therefore:

• Individuals with certain genetic profiles may experience more significant benefits or side effects.
• Further research is needed to understand the relationship between Terminalia Arjuna and genetic variations.

Genetic testing and personalized medicine approaches could potentially optimize the use of Terminalia Arjuna in the future.

Terminalia Arjuna Research Summary

Cancer Research

• Ethanolic extract from Terminalia arjuna seeds showed 90% toxicity against DLA tumor cells and increased the lifespan of mice with cancer by up to 87.5%.
• Extract administration improved blood parameters in mice, suggesting potential tumor recovery.
• A new ellagitannin compound named arjunin, along with other known compounds, was isolated from T. arjuna, which may contribute to its anticancer properties.
• Casuarinin from T. arjuna bark induced apoptosis in human breast adenocarcinoma MCF-7 cells, potentially via p21/WAF1 upregulation and Fas/Fas ligand activation.
• T. arjuna bark extract induced apoptosis in the HepG2 human liver cancer cell line, suggesting cytotoxic potential.

Cardiovascular Research

• Extracts from T. arjuna bark demonstrated lipid-lowering and antioxidant effects in rats with hyperlipidemia, potentially aiding in the prevention of coronary artery disease.
• The plant has been traditionally used as a heart tonic and shows promise for coronary artery disease, heart failure, and high cholesterol management.
• Studies indicate that T. arjuna improves endothelial function in chronic smokers and has a gastroprotective effect against ulcers.
• Used in combination with Ashwagandha, T. arjuna was found to enhance physical performance and cardiorespiratory endurance in healthy young adults.
• An aqueous extract of T. arjuna exhibited hepatoprotective properties, countering oxidative stress in liver cells.

Antioxidant and Anti-inflammatory Research

• T. arjuna extracts showed antioxidant effects on isolated rat kidneys and protected against genetic damage.
• The plant's bark extracts demonstrated antimicrobial properties and potential for treating bacterial ear infections.
• Arjunolic acid from T. arjuna bark mitigated cadmium-induced liver damage and arsenic-induced testicular damage in mice.
• The plant's aqueous extract protected against oxidative stress in heart and kidney tissues from carbon tetrachloride damage.

Diabetes and Metabolic Research

• T. arjuna bark extract showed antidiabetic effects in rats, improving carbohydrate metabolism enzyme profiles and reducing serum and tissue markers associated with hepatocellular carcinoma.
• Herbal extracts including T. arjuna inhibited α-amylase activity, suggesting potential for managing postprandial hyperglycemia in diabetes.

Extraction and Isolation Research

• Microwave-assisted extraction technique was optimized for the efficient extraction of arjunic and arjunolic acids from T. arjuna stem bark.
• A new triterpene diglucoside, terminolitin, and other compounds were discovered in the fruits and bark of T. arjuna.

Other Research Areas

• T. arjuna extracts were found to reduce cholesterol and triglyceride levels in rats after poloxamer 407 injection.
• The plant's bark extract was effective against atherosclerosis in hypercholesterolemic rabbits, suggesting potential for preventing arterial plaque formation.
• Arjunolic acid exhibited cytotoxic effects on Ehrlich ascites carcinoma and Dalton's lymphoma cell lines.

References:

1. Protective effects of ethanolic extract residue isolated from the bark of Terminalia Arjuna against DLA tumour cells
2. Anti-hyperlipidemic and antioxidant potential of different fractions of Terminalia arjuna Roxb. bark against PX- 407 induced hyperlipidemia
3. A tannin anti-cancer promotor from Terminalia arjuna
4. Terminalia arjuna
5. Casuarinin from the bark of Terminalia arjuna induces apoptosis and cell cycle arrest in human breast adenocarcinoma MCF-7 cells
6. Effects of Terminalia arjuna bark extract on apoptosis of human hepatoma cell line HepG2
7. Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults
8. Aqueous extract of Terminalia arjuna attenuates tert-butyl hydroperoxide-induced oxidative stress in HepG2 cell model
9. Terminalia arjuna reverses impaired endothelial function in chronic smokers
10. Mitral regurgitation in early myocardial infarction. Incidence, clinical detection, and prognostic implications. TIMI Study Group
11. Terminalia arjuna's antioxidant effect in isolated perfused kidney
12. Efficacy of Terminalia arjuna (Roxb.) on N-nitrosodiethylamine induced hepatocellular carcinoma in rats
13. Effect of Terminalia arjuna on antioxidant defense system in cancer
14. Salutary effect of Terminalia Arjuna in patients with severe refractory heart failure
15. Botanical influences on cardiovascular disease
16. Microwave extraction and rapid isolation of arjunic acid from Terminalia arjuna (Roxb. ex DC.) stem bark and quantification of arjunic acid and arjunolic acid using HPLC-PDA technique
17. Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro
18. A new triterpene glycoside from Terminalia arjuna
19. 18,19-secooleanane type triterpene glycosyl esters from the bark of Terminalia arjuna
20. Herbal treatment for cardiovascular disease the evidence based therapy
21. Ursane triterpenoids from the bark of Terminalia arjuna
22. Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer
23. Ulcer protective effect of Terminalia arjuna on gastric mucosal defensive mechanism in experimental rats
24. Effect of Terminalia arjuna extract on adriamycin-induced DNA damage
25. Effect of terminalia arjuna stem bark extract on the activities of marker enzymes in alloxan induced diabetic rats
26. Protective effects of Terminalia arjuna against Doxorubicin-induced cardiotoxicity
27. Phytomedicinal activity of Terminalia arjuna against carbon tetrachloride induced cardiac oxidative stress
28. Thyroid hormone regulates mRNA expression and currents of ion channels in rat atrium
29. Triterpenoids from two Terminalia species
30. Taxol production by Pestalotiopsis terminaliae, an endophytic fungus of Terminalia arjuna (arjun tree)
31. Casuarinin protects cultured MDCK cells from hydrogen peroxide-induced oxidative stress and DNA oxidative damage
32. Antigenotoxic properties of Terminalia arjuna bark extracts
33. Antimutagenic activities of acetone and methanol fractions of Terminalia arjuna
34. Baroreflex and chemoreflex dysfunction in streptozotocin-diabetic rats
35. Antimicrobial activity of Terminalia arjuna Wight & Arn.: an ethnomedicinal plant against pathogens causing ear infection
36. Efficacy of Terminalia arjuna in chronic stable angina: a double-blind, placebo-controlled, crossover study comparing Terminalia arjuna with isosorbide mononitrate
37. Inhibitory potential of traditional herbs on α-amylase activity
38. Antitumour activity of Terminalia arjuna leaf against Ehrlich ascites carcinoma in mice
39. Cardio-protective role of Terminalia arjuna bark extract is possibly mediated through alterations in thyroid hormones
40. Antioxidant activity of Terminalia arjuna bark extract on N-nitrosodiethylamine induced hepatocellular carcinoma in rats
41. Triterpene glycoside from Terminalia arjuna
42. Terminalia arjuna improves cardiovascular autonomic neuropathy in streptozotocin-induced diabetic rats
43. Arjunolic acid, a triterpenoid saponin, ameliorates arsenic-induced cyto-toxicity in hepatocytes
44. Mechanistic clues in the cardioprotective effect of Terminalia arjuna bark extract in isoproterenol-induced chronic heart failure in rats
45. A novel endophytic Taxol-producing fungus Chaetomella raphigera isolated from a medicinal plant, Terminalia arjuna
46. Effect of methanolic extract of Terminalia arjuna against Helicobacter pylori 26695 lipopolysaccharide-induced gastric ulcer in rats
47. Role of Terminalia arjuna in ischaemic mitral regurgitation
48. Beneficial effects of Terminalia arjuna in coronary artery disease
49. Indigenous drugs in ischemic heart disease in patients with diabetes
50. Terminalia arjuna protects mouse hearts against sodium fluoride-induced oxidative stress
51. Terminalia Arjuna (Roxb.) Modulates Circulatory Antioxidants on 7,12-dimethylbenz(a)anthracene- induced Hamster Buccal Pouch Carcinogenesis
52. Terminalia arjuna Wight & Arn.--a useful drug for cardiovascular disorders
53. Terminalia arjuna (Roxb.) protects rabbit heart against ischemic-reperfusion injury: role of antioxidant enzymes and heat shock protein
54. Cardioprotective effect of the alcoholic extract of Terminalia arjuna bark in an in vivo model of myocardial ischemic reperfusion injury
55. Effect of oleanane triterpenoids from Terminalia arjuna--a cardioprotective drug on the process of respiratory oxyburst
56. Cytotoxic agents from Terminalia arjuna
57. The aqueous extract, not organic extracts, of Terminalia arjuna bark exerts cardiotonic effect on adult ventricular myocytes
58. Two new bioactive oleanane triterpene glycosides from Terminalia arjuna
59. Protection of arsenic-induced testicular oxidative stress by arjunolic acid
60. Terminalia arjuna in cardiovascular diseases: making the transition from traditional to modern medicine in India
61. Mechanism of poloxamer 407-induced hypertriglyceridemia in the rat
62. Anti-Atherogenic Activity of Ethanolic Fraction of Terminalia arjuna Bark on Hypercholesterolemic Rabbits
63. Isolation, characterisation and cytotoxicity study of arjunolic acid from Terminalia arjuna
64. Terminalia arjuna enhances baroreflex sensitivity and myocardial function in isoproterenol-induced chronic heart failure rats
65. Induction of cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells by casuarinin from the bark of Terminalia arjuna Linn
66. Quantitative determination of oleane derivatives in Terminalia arjuna by high performance thin layer chromatography
67. In vitro Evaluation of Terminalia arjuna on Calcium Phosphate and Calcium Oxalate Crystallization
68. Catecholamine-induced myocardial fibrosis and oxidative stress is attenuated by Terminalia arjuna (Roxb.)
69. Effect of Terminalia arjuna stem bark on antioxidant status in liver and kidney of alloxan diabetic rats
70. Terminoside A, a new triterpene glycoside from the bark of Terminalia arjuna inhibits nitric oxide production in murine macrophages
71. Antidyslipidemic and antioxidant activities of different fractions ofTerminalia arjuna stem bark
72. A new cardenolide from the seeds of Terminalia arjuna (W&A)
73. Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders
74. Estimation of genetic diversity and evaluation of relatedness through molecular markers among medicinally important trees: Terminalia arjuna, T. chebula and T. bellerica
75. A new cardenolide from the roots of Terminalia arjuna
76. A novel naphthanol glycoside from Terminalia arjuna with antioxidant and nitric oxide inhibitory activities
77. Antihyperglycemic activity and antioxidant role of Terminalia arjuna leaf in streptozotocin-induced diabetic rats
78. Simultaneous determination and characterization of tannins and triterpene saponins from the fruits of various species of Terminalia and Phyllantus emblica using a UHPLC-UV-MS method: application to triphala
79. Beta-thalassemia, hyperlipoproteinemia(a), and metabolic syndrome: its low-cost holistic therapy
80. Cardiac changes in subclinical and overt hyperthyroid women: retrospective study
81. Arjunic acid, a strong free radical scavenger from Terminalia arjuna

Upload Whole Genome Sequencing (WGS) raw DNA data today and take a deep dive into your genome!

Or if you only have standard microarray data currently, upload raw DNA data to get started with your free DNA raw data analysis today!