Phenylpiracetam - NutraPedia

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Phenylpiracetam Information

1. Conditions Studied

Phenylpiracetam has been studied for a variety of conditions including:

  • Cognitive disorders
  • Depression
  • Anxiety
  • Physical performance enhancement
  • Stroke recovery
  • Chronic fatigue syndrome

2. Efficacy in Treating Conditions

Research on phenylpiracetam's effectiveness in treating these conditions is mixed. Some studies suggest potential benefits in improving cognitive function, mood, and physical performance, but further research is needed to confirm these effects and to establish appropriate dosing and safety guidelines.

3. Health Benefits

Reported health benefits of phenylpiracetam include:

  • Enhanced cognitive function and memory
  • Increased physical stamina and resistance to cold
  • Neuroprotective effects
  • Potential mood improvement

4. Downsides

While phenylpiracetam is considered safe for many, it may have downsides, such as:

  • Potential for abuse and development of tolerance
  • Headaches, irritability, or insomnia with high doses or prolonged use
  • Insufficient long-term safety data
  • Limited availability and legal status in some regions

5. Genetic Variations

There is limited research on the interaction between phenylpiracetam and specific genetic variations. Some individuals may metabolize drugs differently due to genetic differences, which can influence the drug's efficacy and risk of side effects. However, no specific genetic variations have been conclusively identified as making phenylpiracetam either particularly beneficial or harmful.

Phenylpiracetam Research Summary

Overview of Phenylpiracetam

Phenylpiracetam is a potent nootropic drug belonging to the subgroup of piracetam-like compounds used for its neuroprotective and cognitive-enhancing properties. It is considered more effective than piracetam and has shown promise in a variety of applications, including improving motor and cognitive functions, and it has demonstrated psychoimmunomodulatory effects in animal studies.

Clinical Outcomes and Applications

  • Phenylpiracetam has been effective in reducing neurological deficits, preserving motor skills, and improving memory and local blood flow in ischemic conditions in rats.
  • It has shown to be more effective than piracetam at enhancing operant behavior, counteracting depressive effects, reducing nystagmus, and preventing memory loss, with additional anticonvulsant properties.
  • In human studies, Phenylpiracetam at a dose of 200 mg per day significantly improved motor dysfunctions, cognitive functions, and increased mobility and daily activity in patients with encephalopathy from various chronic brain conditions.
  • The drug also positively affected recovery of neurological functions and daily living activities in ischemic stroke patients during rehabilitation.
  • Phenylpiracetam alleviated anxiety and fear, increased locomotion and exploratory behavior, and improved immune reactivity in rats experiencing immune stress.

Pharmacology and Toxicology

The pharmacological mechanisms of Phenylpiracetam are not fully understood. It is thought to act on glutamate receptors and may stimulate calcium influx into neurons. Toxicology reports suggest that high doses can cause depressive effects.

Detection Method

A detection method for carphedon (Phenylpiracetam) in human urine using solid-phase microextraction and gas chromatography has been developed, improving the sensitivity and simplicity of doping tests.

Conclusion

Phenylpiracetam exhibits significant improvements in clinical outcomes for CNS disorders, with a broad spectrum of beneficial effects on cognitive and motor functions, as well as psychological and immune responses.

References:


  1. Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders
  2. [Comparative evaluation of the neuroprotective activity of phenotropil and piracetam in laboratory animals with experimental cerebral ischemia]
  3. [Pharmacological characteristics of a new phenyl analog of piracetam--4-phenylpiracetam]
  4. Determination of carphedon in human urine by solid-phase microextraction using capillary gas chromatography with nitrogen-phosphorus detection
  5. Investigation into stereoselective pharmacological activity of phenotropil
  6. [Phenotropil in the treatment of vascular encephalopathy]
  7. [The phenotropil treatment of the consequences of brain organic lesions]
  8. [Use of phenotropil in the treatment of asthenic syndrome and autonomic disturbances in the acute period of mild cranial brain trauma]
  9. [The efficacy of phenotropil in the complex treatment of epilepsy]
  10. [The clinical and immunological aspects of the effects of phenotropil on consequences of stroke]
  11. [Efficacy of phenotropil in the rehabilitation of stroke patients]
  12. Psychoimmunomodulatory effect of phenotropil in animals with immune stress


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