Dendrobium Research Summary

The Dendrobium genus, used in traditional Eastern Asian medicine, has been the focus of various research studies due to its wide range of medicinal properties.

Medicinal Properties and Bioactive Components

Studies have identified multiple bioactive components in Dendrobium species including enzymes, lectins, polysaccharides, and alkaloids. These compounds are known for their antioxidant, anticancer, neuroprotective, and immunomodulatory effects. Polysaccharides, in particular, have shown immunomodulatory and liver-protecting effects.

Species Identification and Conservation

Research has developed methods to differentiate authentic Dendrobium drugs from counterfeits and to identify specific species used medicinally, such as Dendrobium catenatum, due to the dwindling wild resources.

Pharmacological Studies

Denbinobin from Dendrobium moniliforme has been studied for its anti-tumor and anti-inflammatory properties, affecting the NF-kappaB pathway and inducing apoptosis in leukemic cells. Phenanthrenes from Dendrobium nobile have shown potential as antifibrotic agents in liver fibrosis. SG-168, another compound from Dendrobium nobile, has demonstrated neuroprotective effects against oxidative stress-induced cell death. Additionally, Dendrobium alkaloids have been found to improve memory impairment in rats.

Molecular Biology in Medicinal Identification

Techniques like ISSR-PCR have been employed to identify different species and origins of medicinal Dendrobium for quality control purposes.

Anti-Aging and Anti-Cancer Studies

Compounds like dendroflorin and moscatilin have been researched for their effects on cell proliferation and aging, as well as their potential to hinder tumor growth and angiogenesis.

Novel Compounds and Antioxidant Properties

Several new compounds, including bibenzyl derivatives and phenanthrenes, have been isolated from various Dendrobium species and demonstrated strong antioxidant activities.

Neuroprotective Studies

Compounds like chrysotoxine have been shown to protect dopaminergic neurons from neurotoxicity, highlighting the therapeutic potential of Dendrobium species in neurodegenerative diseases.

Immunomodulatory Research

Research on Dendrobium species has also delved into immunomodulatory effects, such as the influence of Dendrobium officinale polysaccharides on Sjögren's syndrome and atopic dermatitis, indicating potential treatment options for these conditions.

References:

1. Review of research on Dendrobium, a prized folk medicine
2. Identification of dendrobium species used for herbal medicines based on ribosomal DNA internal transcribed spacer sequence
3. Denbinobin inhibits nuclear factor-kappaB and induces apoptosis via reactive oxygen species generation in human leukemic cells
4. Selective apoptosis in hepatic stellate cells mediates the antifibrotic effect of phenanthrenes from Dendrobium nobile
5. Neuroprotective effects of SG-168 against oxidative stress-induced apoptosis in PC12 cells
6. Inhibitory effects of Dendrobium alkaloids on memory impairment induced by lipopolysaccharide in rats
7. The structure of dendroxine. The third alkaloid from Dendrobium nobile
8. [Identification of medical Dendrobium herbs by ISSR marker]
9. Dendroflorin retards the senescence of MRC-5 cells
10. Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo
11. Four new bibenzyl derivatives from Dendrobium candidum
12. Three new bibenzyl derivatives from Dendrobium candidum
13. Chrysotoxine, a novel bibenzyl compound selectively antagonizes MPP⁺, but not rotenone, neurotoxicity in dopaminergic SH-SY5Y cells
14. Copacamphane, picrotoxane, and alloaromadendrane sesquiterpene glycosides and phenolic glycosides from Dendrobium moniliforme
15. A new phenanthrenequinone from Dendrobium draconis
16. A new bibenzyl from Dendrobium secundum
17. Two novel bibenzyls from Dendrobium trigonopus
18. Isolation and structural characterization of a neutral polysaccharide from the stems of Dendrobium densiflorum
19. Dendrobium findleyanum agglutinin: production, localization, anti-fungal activity and gene characterization
20. Isolation and characterization of chalcone synthase gene isolated from Dendrobium Sonia Earsakul
21. Dihydroayapin, a new coumarin compound from Dendrobium densiflorum
22. [Molecular cloning and expression analysis of sucrose synthase gene from Dendrobium officinale]
23. [Chemical constituents of Dendrobium candidum]
24. [Studies on the chemical constituents of Dendrobium fimbriatum]
25. Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome
26. Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjögren's syndrome patients
27. Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation
28. Dendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental Sjögren's syndrome mice
29. Antifibrotic phenanthrenes of Dendrobium nobile stems
30. Preventive effect of a galactoglucomannan (GGM) from Dendrobium huoshanense on selenium-induced liver injury and fibrosis in rats
31. Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells
32. Denbinobin, a naturally occurring 1,4-phenanthrenequinone, inhibits HIV-1 replication through an NF-kappaB-dependent pathway
33. Orally administered Dendrobium officinale and its polysaccharides enhance immune functions in BALB/c mice
34. A pilot study evaluating the clinical and immunomodulatory effects of an orally administered extract of Dendrobium huoshanense in children with moderate to severe recalcitrant atopic dermatitis

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