DAO (AOC1) and Histamine: How Your Genes Affect Breakdown and Tolerance

Introduction

“DAO” is a common shorthand for the enzyme encoded by the AOC1 gene. Its primary role is degrading extracellular histamine, particularly in the gut. People with lower‑function variants may experience symptoms after histamine‑rich meals.

Biology in Brief

• Substrate: Histamine outside the cell (e.g., in the lumen after meals).
• Location: GI tract and other tissues exposed to circulating histamine.
• Counterpart: HNMT manages intracellular histamine.

Genetic Variation

Functional differences in AOC1 (DAO) can change enzyme abundance or activity. Lower activity correlates with higher symptom risk under load.

Real‑World Clues

• Reactions to aged/fermented foods or alcohol
• Symptoms tied to meal timing and composition
• Allergy‑like symptoms without clear allergen triggers

Personal Strategy

• Define threshold via structured dietary trials.
• Address gut health and inflammatory context.
• Discuss clinical support based on genetics and response.

Testing with NutraHacker

The Histamine Panel integrates AOC1 (DAO) with HNMT to outline your histamine‑handling profile.

FAQs

Why does NutraHacker use AOC1 instead of DAO?

AOC1 is the gene name; DAO is a common historical label for the enzyme. We standardize on AOC1 for clarity.

Can improving gut health change tolerance?

Often, yes. It may influence endogenous histamine production and barrier integrity.

Is AOC1 the only factor?

No. HNMT, immune activity, microbiome, and diet all contribute.