Maturity-onset diabetes of the young
February 3, 2023
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Maturity-onset diabetes of the young (MODY) is a rare, inherited form of diabetes that affects people under the age of 25. MODY is caused by mutations in genes that regulate insulin secretion and glucose metabolism, leading to high blood sugar levels. Unlike type 1 diabetes and type 2 diabetes, MODY is not caused by an autoimmune reaction or insulin resistance, but by a genetic deficiency in the insulin-producing cells of the pancreas.
There are different types of MODY, each caused by mutations in a different gene, and they can present differently in terms of symptoms and progression. The most common forms of MODY are caused by mutations in the HNF1A, GCK, and HNF4A genes.
The diagnosis of MODY can be challenging, as the symptoms can be similar to those of type 1 and type 2 diabetes. MODY is usually diagnosed through a combination of medical history, physical exam, blood tests, and genetic testing. Management of MODY may include lifestyle changes, such as diet and exercise, as well as medications to control blood sugar levels. In some cases, insulin injections may also be necessary. Early diagnosis and management are important to prevent or minimize the long-term complications of diabetes, such as heart disease, stroke, and damage to the eyes, nerves, and kidneys.
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