Gene HNF1A

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Also known as

HNF1, LFB1, TCF1, HNF4A, MODY3, TCF-1, HNF-1A, IDDM20, HNF1alpha, HNF-1-alpha


HNF1A is a gene that codes for a protein called hepatocyte nuclear factor 1 alpha. This protein plays a role in the development and function of the liver, pancreas, and kidneys. Mutations in the HNF1A gene can cause a genetic disorder called maturity-onset diabetes of the young type 5 (MODY5). This is a rare form of diabetes that typically develops in young adulthood and is characterized by high blood sugar levels that are not well-controlled with standard treatments for diabetes. MODY5 is caused by problems with insulin production, and it can run in families. It is usually diagnosed based on the presence of high blood sugar levels and a family history of the condition. Treatment for MODY5 may include the use of medications to lower blood sugar levels and lifestyle changes such as diet and exercise.

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