Gene VKORC1

Also known as

VKCFD2, vitamin K epoxide reductase complex subunit 1

Overview

VKORC1 (Vitamin K Epoxide Reductase Complex Subunit 1) encodes the enzyme responsible for recycling vitamin K, which is essential for the activation of clotting factors II, VII, IX, and X. This enzyme is the target of warfarin and other coumarin anticoagulants, which work by inhibiting VKORC1 and thereby reducing the production of functional clotting factors.

Genetic variants in VKORC1 are major determinants of warfarin dose requirements. The -1639G>A polymorphism (rs9923231) is particularly important, with the A allele associated with lower VKORC1 expression and significantly reduced warfarin dose requirements. This variant is common, with the A allele frequency reaching over 90% in some Asian populations.

Combined testing of VKORC1 and CYP2C9 allows for pharmacogenetically-guided warfarin dosing, which has been shown to improve time to stable INR and reduce adverse events. Understanding your VKORC1 status is valuable if you ever need anticoagulation therapy with warfarin, enabling safer and more effective treatment.

NutraHacker Raw DNA Analysis Products that include this gene

• Complete Mutation Nutrition Report
• WGS True Pharmacogenetics Panel

Upload raw DNA data to get your very own analysis of gene VKORC1 through your personalized DNA reports.