Gene TRHR
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Also known as
Thyrotropin-releasing hormone receptor, TRH-ROverview
TRHR (Thyrotropin-Releasing Hormone Receptor) encodes the receptor for thyrotropin-releasing hormone (TRH), a key regulator of the hypothalamic-pituitary-thyroid axis. This receptor is primarily expressed in the anterior pituitary gland, where TRH binding stimulates the release of thyroid-stimulating hormone (TSH), which in turn regulates thyroid hormone production.Genetic variants in TRHR can affect thyroid hormone regulation and have been associated with central hypothyroidism, a condition characterized by low thyroid hormone levels due to inadequate TSH secretion rather than thyroid gland dysfunction. This can manifest as fatigue, weight gain, cold intolerance, and cognitive impairment. Unlike primary hypothyroidism, central hypothyroidism may be more difficult to diagnose as TSH levels may be inappropriately normal or only slightly elevated.
The TRHR gene also plays roles beyond thyroid regulation, including involvement in metabolic processes and potentially influencing depression and mood disorders. Understanding TRHR genetic variation can provide insights into thyroid function, metabolic health, and personalized approaches to thyroid hormone replacement therapy.