Gene TRDN

Also known as

Triadin, TDN

Overview

TRDN (Triadin) encodes a protein critical for cardiac muscle contraction and calcium regulation within the sarcoplasmic reticulum of heart muscle cells. Triadin acts as a structural and regulatory component of the calcium release complex, mediating the interaction between ryanodine receptors and calsequestrin to ensure proper calcium handling during each heartbeat.

Mutations in TRDN can disrupt this calcium regulation, leading to potentially life-threatening arrhythmias. Pathogenic variants have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), a condition characterized by abnormal heart rhythms triggered by physical or emotional stress. This can result in syncope, seizures, or sudden cardiac death, particularly in young individuals.

Understanding TRDN genetic status is important for carrier screening and family planning, as well as for identifying individuals at risk for cardiac arrhythmias who may benefit from lifestyle modifications, beta-blocker therapy, or implantable cardioverter-defibrillator placement.

NutraHacker Raw DNA Analysis Products that include this gene

• Whole Genome Sequencing Critical Genetics Report

Upload raw DNA data to get your very own analysis of gene TRDN through your personalized DNA reports.