Gene PPARGC1B
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Also known as
PPARG coactivator 1 beta, PGC-1beta, PERCOverview
PPARGC1B (PPARG Coactivator 1 Beta) encodes PGC-1beta, a transcriptional coactivator that partners with nuclear receptors to regulate mitochondrial biogenesis, oxidative metabolism, and thermogenesis. While related to PGC-1alpha, PGC-1beta has distinct functions, particularly in regulating fat metabolism in brown adipose tissue and liver lipogenesis.Variants in PPARGC1B have been associated with body composition, fat distribution, and metabolic traits. The gene influences the ratio of oxidative to glycolytic muscle fibers and affects how efficiently the body burns fat during exercise. PPARGC1B polymorphisms may also influence the response to exercise training and susceptibility to metabolic syndrome.
Understanding your PPARGC1B genetic status provides insights into fat metabolism and body composition. This information is relevant for understanding individual differences in energy expenditure, fat storage patterns, and potentially optimizing exercise and dietary strategies for metabolic health.