Gene PPARD
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Also known as
peroxisome proliferator activated receptor delta, PPAR-delta, NUC1, NR1C2Overview
PPARD (Peroxisome Proliferator Activated Receptor Delta) encodes a nuclear receptor that regulates fatty acid oxidation, energy homeostasis, and exercise adaptation. Upon ligand binding, PPARD activates transcription of genes involved in fat metabolism, particularly in skeletal muscle and adipose tissue. It is a key regulator of the switch from glucose to fatty acid oxidation during exercise.The rs2016520 variant in PPARD has been extensively studied for its effects on endurance performance and metabolic health. This polymorphism influences exercise adaptation, with certain genotypes associated with enhanced aerobic capacity and improved response to endurance training. PPARD variants also affect lipid profiles and diabetes risk.
Understanding your PPARD genetic status provides insights into metabolic flexibility and exercise response. This information is relevant for optimizing training strategies, understanding fat metabolism capacity, and potentially predicting response to lifestyle interventions for metabolic health.