Gene OPRM1
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Also known as
MOR, MOR1, LMOR, mu opioid receptor 1Overview
OPRM1 (Opioid Receptor Mu 1) encodes the mu opioid receptor, the primary target for opioid analgesics including morphine, codeine, fentanyl, and oxycodone. This receptor mediates the pain-relieving, euphoric, and addictive properties of opioid drugs and also binds endogenous opioid peptides like endorphins.The A118G polymorphism (rs1799971) is the most studied OPRM1 variant. The G allele has been associated with reduced receptor expression and altered opioid response, with some studies suggesting carriers may require higher opioid doses for adequate pain control. This variant has also been studied in relation to addiction susceptibility and naltrexone treatment response for alcohol dependence.
Understanding your OPRM1 genetic status has important implications for pain management and addiction treatment. This pharmacogenetic information can help guide opioid prescribing decisions and predict response to addiction medications, contributing to more personalized and effective treatment approaches.