Gene NTRK2
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Also known as
neurotrophic receptor tyrosine kinase 2, tropomyosin receptor kinase B, TrkB, BDNF receptorOverview
NTRK2 (Neurotrophic Receptor Tyrosine Kinase 2) encodes TrkB, the primary receptor for brain-derived neurotrophic factor (BDNF). When BDNF binds to TrkB, it activates signaling pathways that promote neuronal survival, growth, and synaptic plasticity. This receptor is essential for normal brain development, learning, memory, and mood regulation.Variants in NTRK2 have been associated with obesity, as TrkB signaling in the hypothalamus regulates appetite and energy balance. NTRK2 mutations can cause a severe early-onset obesity syndrome with developmental delay. Common variants may influence eating behavior, body weight, and susceptibility to mood disorders through effects on BDNF signaling efficiency.
Understanding your NTRK2 genetic status provides insights into neurotrophin signaling and its effects on brain function and metabolism. This information is relevant for understanding mood regulation, cognitive function, appetite control, and obesity susceptibility.