Gene NRF1
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Also known as
nuclear respiratory factor 1, alpha palindromic-binding protein, NRF-1Overview
NRF1 (Nuclear Respiratory Factor 1) encodes a transcription factor that activates genes required for mitochondrial biogenesis, cellular respiration, and antioxidant defense. NRF1 regulates expression of nuclear-encoded mitochondrial proteins including components of the electron transport chain and mitochondrial transcription factors. It is a master regulator of cellular energy metabolism.NRF1 works with PGC-1alpha to coordinate mitochondrial biogenesis in response to energy demands like exercise. Variants affecting NRF1 function may influence mitochondrial density, oxidative capacity, and exercise adaptation. Reduced NRF1 activity has been implicated in aging, neurodegenerative diseases, and metabolic disorders characterized by mitochondrial dysfunction.
Understanding your NRF1 genetic status provides insights into mitochondrial function and energy metabolism. This information is relevant for understanding athletic performance potential, aging, and susceptibility to conditions involving mitochondrial dysfunction such as metabolic syndrome and neurodegenerative diseases.