Gene NR3C2
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Also known as
nuclear receptor subfamily 3 group C member 2, mineralocorticoid receptor, MR, aldosterone receptorOverview
NR3C2 (Nuclear Receptor Subfamily 3 Group C Member 2) encodes the mineralocorticoid receptor, which binds aldosterone and cortisol to regulate sodium and potassium balance in the kidney. In the brain, the mineralocorticoid receptor is important for stress response, cognition, and mood regulation. The receptor works in concert with the glucocorticoid receptor to fine-tune HPA axis function.Loss-of-function mutations in NR3C2 cause autosomal dominant pseudohypoaldosteronism type 1, characterized by salt wasting in infancy. Common polymorphisms affecting NR3C2 function have been associated with blood pressure variation, depression susceptibility, and cognitive effects of stress. The brain mineralocorticoid receptor is particularly important for stress resilience and memory consolidation.
Understanding your NR3C2 genetic status provides insights into salt-water balance and stress response. This information is relevant for understanding blood pressure regulation, depression vulnerability, and how stress affects cognitive function, potentially informing stress management strategies.