Gene NR3C1
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Also known as
nuclear receptor subfamily 3 group C member 1, glucocorticoid receptor, GR, GCROverview
NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) encodes the glucocorticoid receptor, a ligand-activated transcription factor that mediates the effects of cortisol and synthetic glucocorticoids. Upon hormone binding, the receptor translocates to the nucleus and regulates genes involved in metabolism, immune function, development, and stress responses. The glucocorticoid receptor is essential for the hypothalamic-pituitary-adrenal axis function.Polymorphisms in NR3C1 affect glucocorticoid sensitivity and stress responses. The BclI and N363S variants alter receptor function and are associated with cortisol response variations, metabolic syndrome features, and depression susceptibility. NR3C1 methylation changes due to early life stress are a key epigenetic mechanism linking adversity to later mental health outcomes.
Understanding your NR3C1 genetic status provides insights into stress response and glucocorticoid sensitivity. This information is relevant for understanding individual differences in stress resilience, depression vulnerability, metabolic health, and potentially response to glucocorticoid medications.