Gene NFATC4
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Also known as
nuclear factor of activated T cells 4, NFAT3, NF-ATc4Overview
NFATC4 (Nuclear Factor of Activated T Cells 4) encodes a transcription factor that is activated by calcium signaling through calcineurin-mediated dephosphorylation. Upon activation, NFATC4 translocates to the nucleus where it regulates gene expression involved in immune responses, cardiac hypertrophy, and muscle development. It is particularly important in cardiac remodeling and adipocyte differentiation.NFATC4 variants have been associated with metabolic traits including obesity and insulin resistance. The gene plays a role in adipogenesis and glucose homeostasis through its transcriptional regulation of metabolic genes. Variants affecting NFATC4 function may influence susceptibility to metabolic syndrome and type 2 diabetes.
Understanding your NFATC4 genetic status provides insights into metabolic regulation and body composition. This information is relevant for understanding genetic contributions to obesity susceptibility and metabolic health, potentially informing personalized approaches to weight management and diabetes prevention.