Gene NF2
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Also known as
neurofibromin 2, merlin, schwannomin, moesin-ezrin-radixin-like proteinOverview
NF2 (Neurofibromin 2) encodes merlin (moesin-ezrin-radixin-like protein), a tumor suppressor that regulates cell growth at the interface between the cytoskeleton and plasma membrane. Merlin integrates growth factor signaling and cell-cell contact inhibition to control proliferation. It is particularly important in Schwann cells that form the myelin sheath around nerves.Mutations in NF2 cause neurofibromatosis type 2 (NF2), characterized by bilateral vestibular schwannomas (acoustic neuromas) that lead to hearing loss, tinnitus, and balance problems. Other nervous system tumors including meningiomas and ependymomas are also common. NF2 typically manifests in young adulthood and requires ongoing surveillance and management.
Understanding your NF2 genetic status provides critical insights into hereditary tumor predisposition. This information is particularly important for individuals with family history of NF2 or those presenting with vestibular schwannomas, enabling early surveillance and treatment planning.